INT22091

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Context Info
Confidence 0.26
First Reported 1990
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.51
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SERPINA3) nucleus (SERPINA3) intracellular (SERPINA3)
DNA binding (SERPINA3)
Anatomy Link Frequency
motoneurons 1
neutrophil 1
SERPINA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 98.48 Very High Very High Very High
Inflammation 16 98.28 Very High Very High Very High
Inflammatory response 9 91.64 High High
Pain 2 83.28 Quite High
headache 1 82.32 Quite High
cINOD 1 73.12 Quite High
Central nervous system 3 43.68 Quite Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 1 99.44 Very High Very High Very High
Cancer 1 99.26 Very High Very High Very High
INFLAMMATION 24 98.28 Very High Very High Very High
Motor Neuron Diseases 107 98.24 Very High Very High Very High
Alzheimer's Dementia 7 97.46 Very High Very High Very High
Neurodegenerative Disease 9 94.76 High High
Syndrome 2 91.12 High High
Sweet's Syndrome 3 90.40 High High
Disease 30 86.08 High High
Autoimmune Disease 2 85.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of SERPINA3, a serine protease inhibitor enriched in neurofilament conglomerates of ALS motoneurons [48], can be seen in the same light and has been associated with other neurodegenerative diseases.
Negative_regulation (inhibitor) of SERPINA3 in motoneurons associated with neurodegenerative disease and motor neuron diseases
1) Confidence 0.26 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.70 Pain Relevance 0
They include beta-amyloid protein; the pentraxins C-reactive protein and amyloid P; complement proteins; the inflammatory cytokines interleukin-1, interleukin-6 and tumor necrosis factor-alpha; the protease inhibitors alpha-2-macroglobulin and alpha-1-antichymotrypsin; and the prostaglandin generating cyclooxygenases COX-1 and COX-2.
Negative_regulation (inhibitors) of alpha-1-antichymotrypsin associated with necrosis, inflammation, cancer, alzheimer's dementia and cytokine
2) Confidence 0.02 Published 2001 Journal Neurobiol. Aging Section Abstract Doc Link 11754986 Disease Relevance 1.23 Pain Relevance 0.30
In affected skin we applied immunohistochemical methods to examine the topographical organization of neutrophil-associated proteinase/proteinase inhibitor systems, i.e. the PMN-elastase/alpha 1-proteinase inhibitor and the cathepsin G/alpha 1-antichymotrypsin systems.
Negative_regulation (inhibitor) of alpha 1-antichymotrypsin in neutrophil
3) Confidence 0.01 Published 1990 Journal Hautarzt Section Abstract Doc Link 2249945 Disease Relevance 0.58 Pain Relevance 0.17

General Comments

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