INT220911

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.08
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (JUN, JUND) cytosol (JUN) nucleoplasm (JUN)
nuclear chromosome (JUN) aging (JUN) DNA binding (JUN)
JUN (Homo sapiens)
JUND (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 15 77.84 Quite High
cytokine 11 70.64 Quite High
Inflammation 11 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 408 98.32 Very High Very High Very High
Osteoarthritis 15 77.84 Quite High
Cancer 25 69.04 Quite High
Necrosis 10 68.48 Quite High
Cervical Cancer 3 7.04 Low Low
Infection 78 5.00 Very Low Very Low Very Low
Death 18 5.00 Very Low Very Low Very Low
Repression 12 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
INFLAMMATION 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
induced c-jun and junD DNA binding activity.
c-jun Binding (activity) of junD
1) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.22 Pain Relevance 0.07
JunD, which is in the AP-1 transcription factor complex like JUN, is also important for inhibiting TNF-stimulated apoptosis.
JUN Binding (complex) of JunD associated with apoptosis
2) Confidence 0.09 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.28 Pain Relevance 0
JunD, which is in the AP-1 transcription factor complex like JUN, is also important for inhibiting TNF-stimulated apoptosis.
AP-1 Binding (complex) of JunD associated with apoptosis
3) Confidence 0.09 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.28 Pain Relevance 0
This induction may be a result of the high induction levels of the genes associated with AP-1 complexes, namely JUN, JUND, and FOSL2.
AP-1 Binding (complexes) of JUND
4) Confidence 0.06 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.31 Pain Relevance 0

General Comments

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