INT22092

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Context Info
Confidence 0.75
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 11.57
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SERPINA3) nucleus (SERPINA3) intracellular (SERPINA3)
DNA binding (SERPINA3)
Anatomy Link Frequency
neuronal 2
globules 2
microglial cells 2
spindle cells 1
U373 MG 1
SERPINA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 97.60 Very High Very High Very High
Pain 19 97.28 Very High Very High Very High
Inflammation 38 91.68 High High
Bile 1 85.96 High High
Analgesic 4 84.84 Quite High
cINOD 8 83.04 Quite High
abdominal pain 5 79.92 Quite High
headache 1 78.56 Quite High
imagery 7 66.20 Quite High
pain flank 1 65.08 Quite High
Disease Link Frequency Relevance Heat
Cancer 54 99.86 Very High Very High Very High
Motor Neuron Diseases 214 99.20 Very High Very High Very High
Anxiety Disorder 4 98.60 Very High Very High Very High
Disease 85 98.52 Very High Very High Very High
Rhinitis 3 98.08 Very High Very High Very High
Synovitis 5 97.60 Very High Very High Very High
Pain 11 97.28 Very High Very High Very High
Cognitive Disorder 2 97.28 Very High Very High Very High
Pressure And Volume Under Development 13 96.56 Very High Very High Very High
Anaplastic Astrocytoma 4 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical studies showed that the tumor cells expressed strong immunoreactivity for vimentin (VIM) and alpha1-antichymotrypsin (?
Gene_expression (expressed) of alpha1-antichymotrypsin associated with cancer
1) Confidence 0.75 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887780 Disease Relevance 0.87 Pain Relevance 0
Electrophoretic mobility shift and reporter gene assays revealed that tepoxalin exerts its inhibitory effect through the inhibition of nuclear factor kappaB (NF-kappaB), a transcription factor involved in the induction of IL-1, IL-6 and ACT gene expression.
Gene_expression (expression) of ACT
2) Confidence 0.75 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10471086 Disease Relevance 0.42 Pain Relevance 0.40
We found that tepoxalin markedly inhibits IL-1beta-induced IL-6 and ACT synthesis in astrocytes and the synthesis of IL-1beta and IL-6 in lipopolysaccharide (LPS)-stimulated microglial cells.
Gene_expression (synthesis) of ACT in microglial cells
3) Confidence 0.75 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10471086 Disease Relevance 0.49 Pain Relevance 0.41
Most of the research suggests that GivE and ACT result in the best outcomes for treating fear-avoidance beliefs in patients with CMP.
Gene_expression (result) of ACT associated with pain and anxiety disorder
4) Confidence 0.65 Published 2010 Journal Cogn Behav Ther Section Abstract Doc Link 19697175 Disease Relevance 0.94 Pain Relevance 0.42
We found that tepoxalin markedly inhibits IL-1beta-induced IL-6 and ACT synthesis in astrocytes and the synthesis of IL-1beta and IL-6 in lipopolysaccharide (LPS)-stimulated microglial cells.
Gene_expression (synthesis) of ACT in microglial cells
5) Confidence 0.65 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10471086 Disease Relevance 0.49 Pain Relevance 0.41
Since cytokines such as interleukin-1 (IL-1) or interleukin-6 (IL-6) as well as acute-phase proteins such as alpha1-anti-chymotrypsin (ACT) participate in the etiopathology of Alzheimer's disease (AD), we were interested whether tepoxalin is able to inhibit the synthesis of these immunomodulators in primary rat microglia and astrocytes as well as in the human astrocytoma cell line U373 MG.
Gene_expression (participate) of ACT in U373 MG associated with anaplastic astrocytoma, disease and cytokine
6) Confidence 0.65 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10471086 Disease Relevance 0.53 Pain Relevance 0.38
The spindle cells were diffuse positive for VIM, ACT, CD68 and negative for desmin, MNF116, SyN, S100, HMB45, and CD117.
Neg (negative) Gene_expression (positive) of ACT in spindle cells
7) Confidence 0.65 Published 2007 Journal Rom J Morphol Embryol Section Abstract Doc Link 18060198 Disease Relevance 0.85 Pain Relevance 0.21
Immunohistochemical study results showed that the tumor cells were positive for vimentin, alpha-1-antichymotrypsin (AACT) and desmin staining, and negative for alpha-fetoprotein (AFP), and eosinophilic hyaline globules in the cytoplasm of some giant cells were strongly positive for periodic acid-Schiff (PAS) staining.
Gene_expression (staining) of AACT in globules associated with rhinitis and cancer
8) Confidence 0.65 Published 2005 Journal World J. Gastroenterol. Section Abstract Doc Link 15682496 Disease Relevance 0.86 Pain Relevance 0.08
Immunohistochemical study results showed that the tumor cells were positive for vimentin, alpha-1-antichymotrypsin (AACT) and desmin staining, and negative for alpha-fetoprotein (AFP), and eosinophilic hyaline globules in the cytoplasm of some giant cells were strongly positive for periodic acid-Schiff (PAS) staining.
Gene_expression (staining) of alpha-1-antichymotrypsin in globules associated with rhinitis and cancer
9) Confidence 0.59 Published 2005 Journal World J. Gastroenterol. Section Abstract Doc Link 15682496 Disease Relevance 0.87 Pain Relevance 0.08
Immunohistochemical tests were positive in lysozyme, alpha-1-antitrypsin, and alpha-1-antichymotrypsin.
Gene_expression (positive) of alpha-1-antichymotrypsin
10) Confidence 0.57 Published 2001 Journal Arthroscopy Section Abstract Doc Link 11154373 Disease Relevance 0.55 Pain Relevance 0.10
During our expression analysis of the motor cortex we identified several candidate genes, such as AQP1, CEBPD, SERPINA3, and the MT1 and MT2 family members, which are exclusively expressed in non-neuronal cells.
Gene_expression (expressed) of SERPINA3 in neuronal
11) Confidence 0.46 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.79 Pain Relevance 0.09
During our expression analysis of the motor cortex we identified several candidate genes, such as AQP1, CEBPD, SERPINA3, and the MT1 and MT2 family members, which are exclusively expressed in non-neuronal cells.
Gene_expression (expression) of SERPINA3 in neuronal
12) Confidence 0.46 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.89 Pain Relevance 0.08
Immunohistochemical studies showed tumor cells to be strongly positive with S-100 protein and weakly positive with alpha-1-antichymotrypsin and vimentin.
Gene_expression (positive) of alpha-1-antichymotrypsin associated with cancer
13) Confidence 0.13 Published 1994 Journal Am J Dermatopathol Section Abstract Doc Link 7802168 Disease Relevance 0.44 Pain Relevance 0.09
Neuron-specific enolase, alpha1-antitrypsin, and alpha1-antichymotrypsin stains performed in 2 cases were strongly positive.
Gene_expression (positive) of alpha1-antichymotrypsin in Neuron
14) Confidence 0.12 Published 2004 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15151205 Disease Relevance 0.55 Pain Relevance 0.08
Immunohistochemically, the tumor cells were positive for vimentin, CD68, alpha-1-antichymotrypsin and alpha-1-antitrypsin.
Gene_expression (positive) of alpha-1-antichymotrypsin associated with cancer
15) Confidence 0.07 Published 2005 Journal J. Oral Pathol. Med. Section Abstract Doc Link 15689235 Disease Relevance 0.78 Pain Relevance 0.08
Cathepsin G, PMN-elastase and alpha 1-antichymotrypsin were found in association with the polymorphonuclear infiltrating cells, whereas alpha 1-proteinase inhibitor was localized exclusively in the subepidermal oedema.
Gene_expression (found) of alpha 1-antichymotrypsin associated with pressure and volume under development
16) Confidence 0.06 Published 1990 Journal Hautarzt Section Abstract Doc Link 2249945 Disease Relevance 0.65 Pain Relevance 0.16
Vimentin and the "histiocytic" determinants (alpha-1-antitrypsin and alpha-1-antichymotrypsin) have been the only consistent immunohistochemical markers expressed by this tumor.
Gene_expression (expressed) of alpha-1-antichymotrypsin associated with cancer
17) Confidence 0.02 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1403776 Disease Relevance 0.60 Pain Relevance 0.10

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