INT220926

Context Info Confidence 0.67 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 12 Total Number 12 Disease Relevance 3.03 Pain Relevance 1.09

peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)

Anatomy Link Frequency chondrocytes 1 proximal 1 MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 161 96.96 Inflammatory stimuli 8 94.28 cytokine 59 87.64 metalloproteinase 120 82.56 Inflammation 88 79.04 Inflammatory mediators 2 77.48 agonist 8 75.00 Arthritis 24 58.12 rheumatoid arthritis 40 5.00 Pain 16 5.00

Disease Link Frequency Relevance Heat Overweight 13 99.58 Chondrosarcoma 49 99.12 Obesity 104 97.20 Osteoarthritis 163 96.96 INFLAMMATION 100 93.96 Necrosis 11 88.68 Cancer 19 88.32 Repression 24 85.96 Arthritis 41 58.12 Arthropathy 19 56.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Endogenous MMP-1 and MMP-13 mRNA expression was unaffected by the overexpression of HA-PPAR?

Transcription (expression) of MMP-13

1) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0

-induced MMP-1 and MMP-13 transcription in the SW-1353 human chondrosarcoma cell line and is associated with a decrease in histone acetylation proximal to the transcription start site in the MMP-1 and MMP-13 promoters [21].

Transcription (transcription) of MMP-13 in proximal associated with chondrosarcoma

2) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.21 Pain Relevance 0.07

The maximum expression of MMP-1 and MMP-13 mRNA with rosiglitazone treatment is approximately 50% of that seen with IL-1?

Transcription (expression) of MMP-13

3) Confidence 0.64 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.14 Pain Relevance 0.17

-induced transcription of MMP-1 and MMP-13 not by a physical blockade of factor binding but through a mechanism involving interaction with HDAC-containing coregulatory complexes and regulation of histone acetylation [12].

Transcription (transcription) of MMP-13

4) Confidence 0.64 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.13 Pain Relevance 0.03

in the AP-1 complex may place the nuclear receptor in a position to more efficiently regulate AP-1-driven transcription of MMP-1 and MMP-13.

Transcription (transcription) of MMP-13

5) Confidence 0.50 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.09 Pain Relevance 0

and RXR ligands rosiglitazone and LG268 may act through similar mechanisms, inhibiting MMP-1 and MMP-13 transcription.

Transcription (transcription) of MMP-13

6) Confidence 0.50 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0.07

Combining LG268 and rosiglitazone had an additive inhibitory effect on MMP-1 and MMP-13 transcription and collagenolysis.

Transcription (transcription) of MMP-13

7) Confidence 0.50 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656243 Disease Relevance 0.07 Pain Relevance 0.07

Real-time RT-PCR was used to quantify MMP mRNA, and Figure 1 demonstrates a dose-dependent inhibition of MMP-1 and MMP-13 mRNA levels in response to rosiglitazone treatment.

Transcription (levels) of MMP-13

8) Confidence 0.50 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.21 Pain Relevance 0.17

resulted in upregulation of mRNA and protein expression of collagenases MMP-1 and MMP-13 and the stromelysin MMP-3.

Transcription (expression) of MMP-13

9) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.32 Pain Relevance 0.12

Pretreatment with 2.5 and 10 mmol/l glucosamine was able, to differing degrees, to downregulate mRNA and protein levels of MMP-1, MMP-3 and MMP-13.

Transcription (levels) of MMP-13

10) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.31 Pain Relevance 0.12

MMP-13 protein and mRNA (Figure 4d) reached maximum levels of 17 ng/ml (P < 0.001) and 400% (P < 0.001), respectively, when Col II was modified with HNE at a 1:20 MR.

Transcription (reached) of MMP-13 protein

11) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.31 Pain Relevance 0.15

The gene encoding TIMP-2 was induced in chondrocytes obtained from normal or overweight patients while mRNA level of MMP-13 or COX-2 was increased in leptin-treated chondrocytes collected from obese OA patients.

Transcription (level) of MMP-13 in chondrocytes associated with obesity, osteoarthritis and overweight

12) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.25 Pain Relevance 0.12

General Comments

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