INT220928

Context Info Confidence 0.47 First Reported 2007 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.93 Pain Relevance 0.33

peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)

Anatomy Link Frequency chondrocytes 2 proximal 2 MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 79 97.88 cytokine 18 88.96 Inflammatory mediators 2 77.48 Arthritis 6 58.84 Inflammation 26 55.44 metalloproteinase 31 50.00 agonist 2 50.00 rheumatoid arthritis 10 5.00 Pain 6 5.00 Analgesic 2 5.00

Disease Link Frequency Relevance Heat Overweight 13 99.58 Chondrosarcoma 13 99.12 Obesity 104 98.12 Osteoarthritis 79 97.88 Necrosis 3 90.00 Cancer 5 89.64 INFLAMMATION 29 77.08 Repression 6 74.32 Arthritis 11 58.84 Arthropathy 6 57.64

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

-induced transcription of MMP-1 and MMP-13 not by a physical blockade of factor binding but through a mechanism involving interaction with HDAC-containing coregulatory complexes and regulation of histone acetylation [12].

Neg (not) Positive_regulation (induced) of Transcription (transcription) of MMP-13

1) Confidence 0.47 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.13 Pain Relevance 0.03

-induced MMP-1 and MMP-13 transcription in the SW-1353 human chondrosarcoma cell line and is associated with a decrease in histone acetylation proximal to the transcription start site in the MMP-1 and MMP-13 promoters [21].

Positive_regulation (induced) of Transcription (transcription) of MMP-13 in proximal associated with chondrosarcoma

2) Confidence 0.47 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.22 Pain Relevance 0.07

resulted in upregulation of mRNA and protein expression of collagenases MMP-1 and MMP-13 and the stromelysin MMP-3.

Positive_regulation (upregulation) of Transcription (expression) of MMP-13

3) Confidence 0.30 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.32 Pain Relevance 0.12

The gene encoding TIMP-2 was induced in chondrocytes obtained from normal or overweight patients while mRNA level of MMP-13 or COX-2 was increased in leptin-treated chondrocytes collected from obese OA patients.

Positive_regulation (increased) of Transcription (level) of MMP-13 in chondrocytes associated with obesity, osteoarthritis and overweight

4) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.26 Pain Relevance 0.12

General Comments

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