INT220938

Context Info Confidence 0.40 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.32 Pain Relevance 0.19

peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)

MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 11 81.48 Osteoarthritis 20 77.60 metalloproteinase 14 75.00 agonist 1 75.00 Inflammation 11 5.00 rheumatoid arthritis 5 5.00 Pain 4 5.00 Arthritis 3 5.00 Analgesic 2 5.00 Inflammatory stimuli 1 5.00

Disease Link Frequency Relevance Heat Necrosis 2 82.52 Cancer 3 82.16 Osteoarthritis 20 77.60 Chondrosarcoma 6 44.72 Hyperplasia 1 17.52 INFLAMMATION 12 5.00 Syndrome 6 5.00 Arthritis 5 5.00 Rheumatoid Arthritis 5 5.00 Repression 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

and RXR ligands rosiglitazone and LG268 may act through similar mechanisms, inhibiting MMP-1 and MMP-13 transcription.

Negative_regulation (inhibiting) of Transcription (transcription) of MMP-13

1) Confidence 0.40 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0.07

Pretreatment with 2.5 and 10 mmol/l glucosamine was able, to differing degrees, to downregulate mRNA and protein levels of MMP-1, MMP-3 and MMP-13.

Negative_regulation (downregulate) of Transcription (levels) of MMP-13

2) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.32 Pain Relevance 0.12

General Comments

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