INT22096

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Context Info
Confidence 0.25
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.63
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SOS1) signal transduction (SOS1) intracellular (SOS1)
DNA binding (SOS1)
Anatomy Link Frequency
monocyte 1
plaque 1
basicranium 1
SOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 89.48 High High
Inflammation 3 89.00 High High
opioid receptor 1 88.96 High High
Opioid 4 86.88 High High
analgesia 1 80.96 Quite High
aspirin 3 50.00 Quite Low
Snapping jaw 2 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gingival Recession 3 100.00 Very High Very High Very High
Adhesions 5 99.30 Very High Very High Very High
Craniosynostosis 1 98.98 Very High Very High Very High
Bordatella Infection 1 95.20 Very High Very High Very High
Hypercalcemia 2 90.56 High High
INFLAMMATION 4 89.00 High High
Stress 2 80.40 Quite High
Osteoarthritis 2 78.48 Quite High
Periodontal Disease 1 75.00 Quite High
Aging 2 29.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that DPDPE-triggered monocyte adhesion requires PI3Kgamma activation and involves Src kinases, the guanine nucleotide exchange factor Vav-1, and the small GTPase Rac1.
Negative_regulation (involves) of guanine nucleotide exchange factor Vav-1 in monocyte associated with adhesions
1) Confidence 0.25 Published 2006 Journal J. Immunol. Section Abstract Doc Link 16424197 Disease Relevance 0.62 Pain Relevance 0.49
Premature fusion of a cranial suture, craniosynostosis, causes flattening of the basicranium, [88] while inhibition of SOS growth creates a more flexed cranial base [12].
Negative_regulation (inhibition) of SOS in basicranium associated with craniosynostosis
2) Confidence 0.13 Published 2009 Journal The Open Dentistry Journal Section Body Doc Link PMC2703201 Disease Relevance 0.33 Pain Relevance 0
This suggests that a decrease in prolidase activity may contribute to a decrease in the biosynthesis of proline-containing proteins, such as collagen and SOS.
Negative_regulation (decrease) of SOS
3) Confidence 0.09 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
The clinical parameters investigated were plaque index (PI), gingival index (GI), pocket probing depth (PPD), loss of attachment (LOA), gingival recession (GR) and gingival fluid flow (GFF).
Negative_regulation (loss) of gingival recession in plaque associated with gingival recession
4) Confidence 0.00 Published 1990 Journal J. Clin. Periodontol. Section Abstract Doc Link 2250079 Disease Relevance 0.68 Pain Relevance 0.23

General Comments

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