INT22098

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Context Info
Confidence 0.69
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 27
Total Number 32
Disease Relevance 14.77
Pain Relevance 14.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
T cells 3
prefrontal 2
natural killer cell 2
cortex 2
macrophages 1
Il2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 155 100.00 Very High Very High Very High
nociceptor 36 100.00 Very High Very High Very High
Analgesic 6 99.98 Very High Very High Very High
fluoxetine 16 99.84 Very High Very High Very High
fibrosis 140 99.80 Very High Very High Very High
withdrawal 1 99.78 Very High Very High Very High
Locus ceruleus 9 99.60 Very High Very High Very High
qutenza 4 99.36 Very High Very High Very High
Pain 7 99.06 Very High Very High Very High
narcan 3 99.06 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 340 100.00 Very High Very High Very High
Cancer 60 100.00 Very High Very High Very High
Necrosis 9 100.00 Very High Very High Very High
Fibrosis 92 99.80 Very High Very High Very High
Nociception 5 99.56 Very High Very High Very High
Bacterial Infection 1 99.38 Very High Very High Very High
INFLAMMATION 138 98.62 Very High Very High Very High
Myocarditis 10 97.36 Very High Very High Very High
Colitis 3 96.92 Very High Very High Very High
Respiratory Syncytial Virus 42 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These behavioral data are compatible with the data for IL-2 levels, which showed that IL-2 levels in the cerebral cortex of HA OVX rats were significantly decreased by all three dosages of dioscorea, while IL-2 levels in the prefrontal cortex of LA OVX rats were increased by dioscorea at 250 mg/kg/day.
Positive_regulation (increased) of IL-2 in cortex associated with anxiety disorder and cerebral cortex
1) Confidence 0.69 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 1.12 Pain Relevance 0.15
Furthermore, a decrease in open arm time and an increase in IL-2 level in the prefrontal cortex of LA OVX rats were seen after treatment with dioscorea at 250 mg/kg/day.
Positive_regulation (increase) of IL-2 in prefrontal associated with anxiety disorder
2) Confidence 0.69 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.83 Pain Relevance 0.17
The present study showed that the anxiogenic effects of 250mg/kg/day of dioscorea in LA OVX rats were accompanied by an increase in IL-2 levels in the prefrontal cortex, while anxiolytic activity in HA OVX rats was accompanied by a decrease in IL-2 levels in the cerebral cortex.
Positive_regulation (increase) of IL-2 in prefrontal associated with anxiety disorder and cerebral cortex
3) Confidence 0.69 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.86 Pain Relevance 0.33
Increased serum IL-2 and IL-6 levels were evident prior to mucosal lesions 2h after induction of colitis and persist up to 14 days (p<0.05 vs. saline), although no histological signs of inflammation were detected at 14 days.
Positive_regulation (Increased) of IL-2 associated with colitis and inflammation
4) Confidence 0.66 Published 2006 Journal Pain Section Abstract Doc Link 16630696 Disease Relevance 0.84 Pain Relevance 0.47
However the level of IL-2 was increased markedly after CAP was given intrathecally.
Positive_regulation (increased) of IL-2 associated with qutenza
5) Confidence 0.66 Published 1995 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Abstract Doc Link 8575048 Disease Relevance 0 Pain Relevance 0.96
IL-4/IL-2 ratio was significantly increased in fluoxetine group respecting the controls and was similar during the 3 weeks of treatment.
Positive_regulation (increased) of IL-2 associated with fluoxetine
6) Confidence 0.55 Published 2009 Journal Int. Immunopharmacol. Section Abstract Doc Link 19189865 Disease Relevance 0.16 Pain Relevance 1.05
After IL-2, JV and protein clearance (JV x L/P) were increased (p less than 0.001) while lymph and plasma total protein content and protein fractionation were unchanged.
Positive_regulation (increased) of IL-2 in plasma
7) Confidence 0.50 Published 1990 Journal Lymphology Section Abstract Doc Link 2250485 Disease Relevance 0.19 Pain Relevance 0.08
Two series of experiments were conducted: in the first series of experiments, IL-2 (1.2 U/3 microliters) was injected twice prior to BK (150 ng/3 microliters) and injected again twice after BK.
Positive_regulation (injected) of IL-2
8) Confidence 0.50 Published 1996 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 8818209 Disease Relevance 0.07 Pain Relevance 0.91
In the first series of experiments, responses to IL-2 were increased by 55% after BK and this difference was statistically significant in a paired-sample t-test (P < 0.02).
Positive_regulation (increased) of IL-2
9) Confidence 0.50 Published 1996 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 8818209 Disease Relevance 0.06 Pain Relevance 0.87
Nevertheless, we found in preliminary studies that BK enhanced the responsiveness of polymodal nociceptors to IL-2 by reversing IL-2-induced tachyphylaxis and increasing response magnitude.
Positive_regulation (enhanced) of IL-2 in nociceptors associated with nociceptor
10) Confidence 0.50 Published 1996 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 8818209 Disease Relevance 0.10 Pain Relevance 0.96
Two series of experiments were conducted: in the first series of experiments, IL-2 (1.2 U/3 microliters) was injected twice prior to BK (150 ng/3 microliters) and injected again twice after BK.
Positive_regulation (injected) of IL-2
11) Confidence 0.50 Published 1996 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 8818209 Disease Relevance 0.07 Pain Relevance 0.91
Levels of LEK increased in both paraventricular hypothalamic nucleus (PVN) and locus ceruleus (LOC) after IL-2 administration, suggesting that the analgesic effect of IL-2 is also related to the change of LEK in PVN and LOC induced by IL-2 administration.
Positive_regulation (effect) of IL-2 in LEK associated with analgesic, locus ceruleus and enkephalin
12) Confidence 0.50 Published 2000 Journal Neuroreport Section Abstract Doc Link 10841362 Disease Relevance 0 Pain Relevance 0.94
In contrast, the anxiogenic effect of dioscorea in LA OVX rats was accompanied by an increase in IL-2 levels in the prefrontal cortex.
Positive_regulation (increase) of IL-2 in cortex associated with anxiety disorder
13) Confidence 0.46 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.90 Pain Relevance 0.29
Fluoxetine administration elevated the levels of IL-4 at 1, 2 and 3 weeks; and of IL-2, at 2 and 3 weeks.
Positive_regulation (elevated) of IL-2 associated with fluoxetine
14) Confidence 0.39 Published 2009 Journal Int. Immunopharmacol. Section Abstract Doc Link 19189865 Disease Relevance 0.17 Pain Relevance 1.05
RESULTS: Microinjection of morphine (0.5 microL, 3672 ng) into PAG region had no influence on IL-6 and TNF-alpha (production of splenic macrophages, suppressed the natural killer cell (NK) activity and enhanced T-lymphocyte functions, including concanavalin A (Con A)-induced T-cell proliferation, IL-2 and TNF-beta production.
Positive_regulation (enhanced) of IL-2 in natural killer cell
15) Confidence 0.34 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 7597910 Disease Relevance 0.16 Pain Relevance 0
Furthermore, Radix Astragali significantly attenuated elevated levels of the Th1 cytokines (IFN-gamma and IL-2), and increased the Th2 cytokines (IL-4 and IL-10) in autoimmune myocarditis.
Positive_regulation (elevated) of IL-2 associated with myocarditis and cytokine
16) Confidence 0.33 Published 2008 Journal Toxicol. Lett. Section Abstract Doc Link 18782607 Disease Relevance 1.47 Pain Relevance 0.37
The levels of TNF-alpha, IL-1 and IL-2 in the serum of AA rats were increased, whereas the level of IL-10 was decreased.
Positive_regulation (increased) of IL-2
17) Confidence 0.33 Published 2009 Journal Acta Pharmacol. Sin. Section Body Doc Link 19169271 Disease Relevance 0.20 Pain Relevance 0
Inhibition of nociceptive withdrawal reflex by microinjection of interleukin 2 into rat locus coeruleus.
Positive_regulation (microinjection) of interleukin 2 in locus coeruleus associated with nociception, locus ceruleus, narcan and withdrawal
18) Confidence 0.32 Published 2000 Journal Neuropeptides Section Title Doc Link 11021983 Disease Relevance 0.28 Pain Relevance 0.57
Furthermore, repetitive gastric fluid aspiration also resulted in increased TGF-beta, TNF-alpha, IL-1alpha, IL-1beta, and IL-2 concentrations in BAL specimens compared to controls, a TH1 cytokine-dominated profile, whereas no increase in TH2 cytokines, such as IL-4, IL-6, and IL-10, was detected.
Positive_regulation (resulted) of IL-2 associated with cytokine
19) Confidence 0.30 Published 2007 Journal Respir Res Section Body Doc Link PMC2213655 Disease Relevance 0.41 Pain Relevance 0.19
Levels of urinary IL-2 are elevated on the first day of spaceflight and again after returning from space.
Positive_regulation (elevated) of IL-2
20) Confidence 0.28 Published 1995 Journal J Gravit Physiol Section Abstract Doc Link 11538892 Disease Relevance 0.20 Pain Relevance 0.24

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