INT221002

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2007
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.79
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COMP) extracellular region (COMP) cell adhesion (COMP)
proteinaceous extracellular matrix (COMP)
Anatomy Link Frequency
cartilage 1
COMP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 53 86.64 High High
imagery 34 50.00 Quite Low
Arthritis 5 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 16 96.28 Very High Very High Very High
Infection 12 90.16 High High
Stress 26 89.88 High High
Knee Osteoarthritis 43 86.64 High High
Obesity 8 70.24 Quite High
Osteoarthritis 10 50.00 Quite Low
Chondrosarcoma 24 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 12 5.00 Very Low Very Low Very Low
Death 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, shRNA 3B was effective at knocking down both WT- and MT-COMP because it was not specifically designed against the mutant COMP mRNA (Fig. 3 and data not shown).
Neg (not) Transcription (designed) of mutant COMP
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.81 Pain Relevance 0
With the exception of COMP, none of the other biomarkers was a statistically significant predictor of cartilage loss.
Neg (exception) Transcription (exception) of COMP in cartilage
2) Confidence 0.54 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212578 Disease Relevance 0.39 Pain Relevance 0.16
By 2 days shRNA 3B reduced COMP protein levels by 90%, and COMP expression was not detectable after 4 days of culture (Fig. 4*) (only MT-COMP results are shown in Fig. 4 because WT-COMP knock down was identical). shRNA 3A was approximately three times less efficient than 3B at reducing COMP protein levels.
Neg (not) Transcription (detectable) of COMP associated with targeted disruption
3) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.60 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox