INT221022

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.38
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10, CCL18) extracellular region (IL10, CCL18) cell-cell signaling (IL10, CCL18)
signal transduction (CCL18) intracellular (IL10) response to stress (IL10)
Anatomy Link Frequency
blood 2
IL10 (Homo sapiens)
CCL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 98 84.00 Quite High
cytokine 12 59.48 Quite High
Inflammation 26 54.56 Quite High
chemokine 84 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 98 84.00 Quite High
INFLAMMATION 32 54.56 Quite High
Arthritis 2 45.12 Quite Low
Disease 10 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low
Neutrophil Disorders 2 5.00 Very Low Very Low Very Low
Crystal Associated Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased responsiveness in SF PMN may be induced by soluble factors present in SF, because preincubation of blood PMN with SF supported the induction of CCL18 by IL-10 alone.
IL-10 Positive_regulation (induction) of CCL18 in blood
1) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.29 Pain Relevance 0.15
IL-10 alone was unable to induce CCL18 in blood PMN, and its release was not enhanced by stimulating PMN with IL-10 in combination with TNF-?.
IL-10 Neg (unable) Positive_regulation (induce) of CCL18 in blood
2) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.08 Pain Relevance 0.07

General Comments

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