INT221026

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.57
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ELANE, CCL18) signal transduction (CCL18) extracellular space (CCL18)
peptidase activity (ELANE) cell-cell signaling (CCL18) cytoplasm (ELANE)
Anatomy Link Frequency
joints 2
ELANE (Homo sapiens)
CCL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 98 99.86 Very High Very High Very High
chemokine 84 87.84 High High
Inflammation 26 29.64 Quite Low
cytokine 12 23.44 Low Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 98 99.86 Very High Very High Very High
INFLAMMATION 32 29.64 Quite Low
Disease 10 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low
Neutrophil Disorders 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Crystal Associated Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because IL-10 is frequently found in SF from patients with RA [31], PMN recruited into joints are likely to contribute to the local production of CCL18.
PMN Spec (likely) Positive_regulation (contribute) of Gene_expression (production) of CCL18 in joints associated with rheumatoid arthritis
1) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.41 Pain Relevance 0.30
in PMN, which in turn induces CCL18 production by PMN in an autocrine manner.


PMN Positive_regulation (induces) of Gene_expression (production) of CCL18
2) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.15 Pain Relevance 0.15

General Comments

This test has worked.

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