INT221027

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ELANE, IL8) signal transduction (IL8) extracellular space (IL8)
peptidase activity (ELANE) intracellular (IL8) cytoplasm (ELANE)
Anatomy Link Frequency
blood 1
ELANE (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 49 90.12 High High
cytokine 21 80.96 Quite High
Inflammation 31 80.60 Quite High
Pain 1 59.52 Quite High
Opioid 2 53.92 Quite High
chemokine 42 51.20 Quite High
Inflammatory response 5 10.28 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urinary Tract Infection 26 99.08 Very High Very High Very High
Adhesions 1 90.64 High High
Rheumatoid Arthritis 49 90.12 High High
INFLAMMATION 38 80.60 Quite High
Stress 7 76.12 Quite High
Pain 1 59.52 Quite High
Injury 2 35.04 Quite Low
Adult Respiratory Distress Syndrome 1 19.68 Low Low
Hepatotoxicity 2 18.64 Low Low
Sepsis 1 18.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies showed that UTI inhibits proinflammatory substances, such as IL-8, which is induced by neutrophilic elastase in human bronchoepithelial cells [4].
neutrophilic elastase Positive_regulation (induced) of IL-8 associated with urinary tract infection
1) Confidence 0.14 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2876852 Disease Relevance 1.06 Pain Relevance 0.25
Results summarized in Figure 1 show a highly upregulated expression of CCL3 and CCL18 mRNAs, a downregulation of CCL21 mRNA (Figure 1a) and an upregulation of CXCL8 and CXCL10 mRNAs (Figure 1b) in SF PMN from each patient in comparison with blood PMN from healthy donors.
PMN Positive_regulation (upregulation) of CXCL8 in blood
2) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.24 Pain Relevance 0.15

General Comments

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