INT221034

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.30
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10, CCL18) extracellular region (IL10, CCL18) cell-cell signaling (IL10, CCL18)
signal transduction (CCL18) intracellular (IL10) response to stress (IL10)
Anatomy Link Frequency
blood 2
PMN 2
IL10 (Homo sapiens)
CCL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 147 99.98 Very High Very High Very High
chemokine 126 84.08 Quite High
Inflammatory mediators 6 56.24 Quite High
Inflammation 39 45.92 Quite Low
cytokine 18 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Crohn's disease 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 147 99.98 Very High Very High Very High
Necrosis 6 91.12 High High
Cancer 6 90.76 High High
INFLAMMATION 48 55.84 Quite High
Disease 15 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Neutrophil Disorders 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Crystal Associated Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, CCL18 could be induced by stimulation of SF PMN with IL-10; indeed, IL-10 in combination with vitamin D3 even enhanced CCL18 release.
IL-10 Positive_regulation (enhanced) of Localization (release) of CCL18
1) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.45 Pain Relevance 0.40
Interestingly, as shown in Figure 4a, neither blood PMN from healthy donors nor blood PMN from patients with RA released significant amounts of CCL18 in response to IL-10 alone or to a combination of IL-10 and TNF-?
IL-10 Positive_regulation (response) of Localization (released) of CCL18 in blood associated with rheumatoid arthritis
2) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.28 Pain Relevance 0.14
In comparison, recruited SF PMN from patients with RA were sensitized for CCL18 production, because IL-10 alone was sufficient to induce CCL18 release.
IL-10 Positive_regulation (induce) of Localization (release) of CCL18 in PMN associated with rheumatoid arthritis
3) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212580 Disease Relevance 0.57 Pain Relevance 0.30

General Comments

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