INT221037

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 7.70
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL18) extracellular space (CCL18) extracellular region (CCL18)
cell-cell signaling (CCL18)
Anatomy Link Frequency
CLC 8
monocyte 3
joint 2
endothelial cell 2
eosinophil 1
CCL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 204 100.00 Very High Very High Very High
Inflammation 202 99.50 Very High Very High Very High
rheumatoid arthritis 196 91.36 High High
aspirin 30 77.00 Quite High
cytokine 30 6.80 Low Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
cocaine 6 5.00 Very Low Very Low Very Low
lidocaine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 102 100.00 Very High Very High Very High
Chronic Sinusitis 84 100.00 Very High Very High Very High
INFLAMMATION 226 99.50 Very High Very High Very High
Arthritis 4 97.72 Very High Very High Very High
Rhinitis 372 95.36 Very High Very High Very High
Polyps 78 94.60 High High
Eczema 186 92.00 High High
Rheumatoid Arthritis 196 91.36 High High
Eosinophilic Esophagitis 30 85.36 High High
Disease 158 74.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether extravasation might have a role in the induction of CCL18 release, PMN and PBMC from healthy donors were co-cultured with the endothelial cell line EA-hy.926.
Positive_regulation (induction) of Localization (release) of CCL18 in endothelial cell
1) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.21 Pain Relevance 0.11
As IL-10 and vitamin D3 are known to have anti-inflammatory properties [41,42], the release of CCL18 induced by these mediators might contribute to a suppression of joint inflammation.
Positive_regulation (induced) of Localization (release) of CCL18 in joint associated with inflammation and arthritis
2) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.58 Pain Relevance 0.29
was found to induce neither the release of CCL18 (Figure 5b) nor the expression of CCL18 mRNA (Figure 5c), suggesting that CCL18 derives from PMN.
Neg (neither) Positive_regulation (induce) of Localization (release) of CCL18
3) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.14 Pain Relevance 0.07
Incubation with both IL-10 and vitamin D3 produced the release of even more CCL18 by PMN preincubated with SF.


Positive_regulation (produced) of Localization (release) of CCL18
4) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.21 Pain Relevance 0.11
Our qRT-PCR results for CCL13, CCL18, CRISP3, EMR3, and IL1RL1 (ST2) (Figure 2) and the increased presence of CLC (Figure 3) and CCL18 [17] protein in separately collected airway specimens from CRS or asthmatic patients, in accordance with their increased mRNA levels in our aCRSwNP patients, further support the validity of our exon array data.
Positive_regulation (increased) of Localization (presence) of CCL18 in CLC associated with asthma and chronic sinusitis
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.60 Pain Relevance 0.13
Our qRT-PCR results for CCL13, CCL18, CRISP3, EMR3, and IL1RL1 (ST2) (Figure 2) and the increased presence of CLC (Figure 3) and CCL18 [17] protein in separately collected airway specimens from CRS or asthmatic patients, in accordance with their increased mRNA levels in our aCRSwNP patients, further support the validity of our exon array data.
Positive_regulation (increased) of Localization (presence) of CCL18 in CLC associated with asthma and chronic sinusitis
6) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.80 Pain Relevance 0.13
These included increased transcription of chemokines localized to chromosome 17q11.2 (CCL13, CCL2, CCL8, and CCL11) that favor eosinophil and monocyte chemotaxis and chemokines (CCL18, CCL22, and CXCL13) that alternatively-activated monocyte-derived cells have been shown to produce.
Positive_regulation (increased) of Localization (localized) of CCL18 in monocyte associated with chemokine
7) Confidence 0.38 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2897889 Disease Relevance 1.86 Pain Relevance 0.18
Our qRT-PCR results for CCL13, CCL18, CRISP3, EMR3, and IL1RL1 (ST2) (Figure 2) and the increased presence of CLC (Figure 3) and CCL18 [17] protein in separately collected airway specimens from CRS or asthmatic patients, in accordance with their increased mRNA levels in our aCRSwNP patients, further support the validity of our exon array data.
Positive_regulation (increased) of Localization (presence) of CCL18 in CLC associated with asthma and chronic sinusitis
8) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.65 Pain Relevance 0.12
Our qRT-PCR results for CCL13, CCL18, CRISP3, EMR3, and IL1RL1 (ST2) (Figure 2) and the increased presence of CLC (Figure 3) and CCL18 [17] protein in separately collected airway specimens from CRS or asthmatic patients, in accordance with their increased mRNA levels in our aCRSwNP patients, further support the validity of our exon array data.
Positive_regulation (increased) of Localization (presence) of CCL18 in CLC associated with asthma and chronic sinusitis
9) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.79 Pain Relevance 0.13
These included increased transcription of chemokines localized to chromosome 17q11.2 (CCL13, CCL2, CCL8, and CCL11) that favor eosinophil and monocyte chemotaxis and chemokines (CCL18, CCL22, and CXCL13) that alternatively-activated monocyte-derived cells have been shown to produce.
Positive_regulation (increased) of in eosinophil Localization (localized) of CCL18 in monocyte associated with chemokine
10) Confidence 0.13 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2897889 Disease Relevance 1.86 Pain Relevance 0.18

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