INT221040

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.19
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCL3) extracellular space (CCL3) extracellular region (CCL3)
intracellular (CCL3) cytoskeleton organization (CCL3) kinase activity (CCL3)
Anatomy Link Frequency
microglia 4
blood 2
CCL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 78 100.00 Very High Very High Very High
Inflammation 81 96.56 Very High Very High Very High
rheumatoid arthritis 49 93.56 High High
cytokine 40 82.32 Quite High
Inflammatory stimuli 2 79.92 Quite High
Central nervous system 30 52.96 Quite High
Inflammatory mediators 16 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 106 96.56 Very High Very High Very High
Rheumatoid Arthritis 49 93.56 High High
Neurodegenerative Disease 20 92.24 High High
Apoptosis 112 79.00 Quite High
Lyme Disease 26 50.00 Quite Low
Infection 12 5.00 Very Low Very Low Very Low
Disease 11 5.00 Very Low Very Low Very Low
Neuroblastoma 10 5.00 Very Low Very Low Very Low
Lyme Neuroborreliosis 10 5.00 Very Low Very Low Very Low
Multiple Sclerosis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results summarized in Figure 1 show a highly upregulated expression of CCL3 and CCL18 mRNAs, a downregulation of CCL21 mRNA (Figure 1a) and an upregulation of CXCL8 and CXCL10 mRNAs (Figure 1b) in SF PMN from each patient in comparison with blood PMN from healthy donors.
Negative_regulation (downregulation) of Gene_expression (expression) of CCL3 in blood
1) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.23 Pain Relevance 0.11
Potent and sustained expression of the chemokines CCL2, CCL3, CCL4 and CCL5, in addition to that of IL-6 and IL-8, contributes to maintaining the inflammatory environment created by microglia in response to B. burgdorferi
Negative_regulation (Potent) of Gene_expression (expression) of CCL3 in microglia associated with chemokine and inflammation
2) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.48 Pain Relevance 0.21
Potent and sustained expression of the chemokines CCL2, CCL3, CCL4 and CCL5, in addition to that of IL-6 and IL-8, contributes to maintaining the inflammatory environment created by microglia in response to B. burgdorferi
Negative_regulation (sustained) of Gene_expression (expression) of CCL3 in microglia associated with chemokine and inflammation
3) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.48 Pain Relevance 0.21

General Comments

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