INT221042

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.84
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL18) extracellular space (CCL18) extracellular region (CCL18)
cell-cell signaling (CCL18)
Anatomy Link Frequency
macrophages 2
blood 2
CCL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 90 100.00 Very High Very High Very High
rheumatoid arthritis 98 95.56 Very High Very High Very High
cytokine 20 83.92 Quite High
fibrosis 3 74.08 Quite High
Inflammation 29 33.36 Quite Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sarcoidosis 40 97.00 Very High Very High Very High
Rheumatoid Arthritis 98 95.56 Very High Very High Very High
Pulmonary Fibrosis 2 74.88 Quite High
Syndrome 19 55.00 Quite High
Disease 19 48.24 Quite Low
Fibrosis 1 45.88 Quite Low
INFLAMMATION 36 33.36 Quite Low
Nicotine Addiction 16 5.00 Very Low Very Low Very Low
Infection 5 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, data are presented to show that the production of CCL18 by PMN is differentially regulated at the levels of mRNA expression and protein synthesis.
Regulation (regulated) of Transcription (expression) of CCL18
1) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.08 Pain Relevance 0.17
As shown in Figure 2a, mRNA expression for two selected chemokines, CCL18 and CXCL10, was readily detectable in SF PMN but remained undetectable in peripheral blood PMN from the healthy donor.
Regulation (undetectable) of Transcription (expression) of CCL18 in blood associated with chemokine
2) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.40 Pain Relevance 0.29
However, another study found no differences in CCL18 mRNA expression between patients and controls, yet in that study total BAL fluid cells and not sorted macrophages were studied [30].
Neg (no) Regulation (differences) of Transcription (expression) of CCL18 in macrophages
3) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.36 Pain Relevance 0.16

General Comments

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