INT221049

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 4.47
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL18) extracellular space (CCL18) extracellular region (CCL18)
cell-cell signaling (CCL18)
Anatomy Link Frequency
sputum 2
blood 2
CCL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 108 94.80 High High
rheumatoid arthritis 98 94.04 High High
aspirin 20 93.76 High High
Inflammation 126 86.64 High High
fibrosis 8 49.76 Quite Low
cytokine 16 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
cocaine 4 5.00 Very Low Very Low Very Low
lidocaine 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eczema 124 99.84 Very High Very High Very High
Asthma 68 99.10 Very High Very High Very High
Infection 4 97.72 Very High Very High Very High
Polyps 52 97.40 Very High Very High Very High
Rhinitis 248 94.92 High High
Rheumatoid Arthritis 98 94.04 High High
Disease 102 91.56 High High
Chronic Sinusitis 56 87.64 High High
INFLAMMATION 140 86.64 High High
Neutrophil Disorders 2 78.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, no mRNA expression was observed for CCL18 and CXCL10 in PMN infected with A. phagocytophilum.


Positive_regulation (observed) of Transcription (expression) of CCL18
1) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.63 Pain Relevance 0.49
Results summarized in Figure 1 show a highly upregulated expression of CCL3 and CCL18 mRNAs, a downregulation of CCL21 mRNA (Figure 1a) and an upregulation of CXCL8 and CXCL10 mRNAs (Figure 1b) in SF PMN from each patient in comparison with blood PMN from healthy donors.
Positive_regulation (upregulated) of Transcription (expression) of CCL18 in blood
2) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.23 Pain Relevance 0.11
We also recently reported increased CCL18 protein levels in induced sputum from asthmatic subjects [17], which is consistent with the increased CCL18 transcription observed here in aCRSwNP.
Positive_regulation (increased) of Transcription (transcription) of CCL18 in sputum associated with asthma
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.70 Pain Relevance 0.05
Both aCRSwNP and AD showed increased transcription of CCL18 (PARC), CCL22 (MDC), and CXCL13.
Positive_regulation (increased) of Transcription (transcription) of CCL18 associated with eczema
4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 1.17 Pain Relevance 0.23
Both aCRSwNP and AD showed increased transcription of CCL18 (PARC), CCL22 (MDC), and CXCL13.
Positive_regulation (increased) of Transcription (transcription) of PARC associated with eczema
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 1.17 Pain Relevance 0.23
In agreement with the exon array data, CCL13, CCL18, EMR3, and IL1RL1 transcription was increased while CRISP3 transcription was decreased in inflamed mucosa and polyp tissue from aCRSwNP subjects.
Positive_regulation (increased) of Transcription (transcription) of CCL18 associated with polyps
6) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.56 Pain Relevance 0.04

General Comments

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