INT221059

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.48
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL21) extracellular region (CCL21) cell-cell signaling (CCL21)
Anatomy Link Frequency
lymph nodes 1
blood 1
CCL21 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 183 100.00 Very High Very High Very High
rheumatoid arthritis 196 97.40 Very High Very High Very High
cytokine 32 96.48 Very High Very High Very High
Inflammation 56 96.08 Very High Very High Very High
Inflammatory mediators 8 75.64 Quite High
cINOD 4 70.00 Quite High
Inflammatory response 5 8.24 Low Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 196 97.40 Very High Very High Very High
INFLAMMATION 69 96.08 Very High Very High Very High
Papillomavirus Infection 18 88.16 High High
Cancer 9 81.92 Quite High
Necrosis 8 81.44 Quite High
Infection 16 79.28 Quite High
Disease 20 68.40 Quite High
Neutrophil Disorders 4 60.48 Quite High
Immunization 15 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Highly upregulated expression of other chemokine genes was observed for CCL3, CXCL8 and CXCL10, whereas CCL21 was downregulated.
Negative_regulation (downregulated) of CCL21 associated with chemokine
1) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212580 Disease Relevance 0.61 Pain Relevance 0.36
Results summarized in Figure 1 show a highly upregulated expression of CCL3 and CCL18 mRNAs, a downregulation of CCL21 mRNA (Figure 1a) and an upregulation of CXCL8 and CXCL10 mRNAs (Figure 1b) in SF PMN from each patient in comparison with blood PMN from healthy donors.
Negative_regulation (downregulation) of CCL21 mRNA in blood
2) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.23 Pain Relevance 0.11
Moreover, because PMN are recruited into SF, a characteristic chemokine expression profile is induced with highly upregulated mRNAs for CCL3, CCL18, CXCL8 and CXCL10 and downregulation of CCL21 mRNA.


Negative_regulation (downregulation) of CCL21 mRNA associated with chemokine
3) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.53 Pain Relevance 0.44
SF PMN from patients with RA exhibit a characteristic chemokine expression pattern resembling the upregulation of CCL3, CCL18, CXCL8 and CXCL10 mRNAs and the downregulation of CCL21 mRNA.
Negative_regulation (downregulation) of CCL21 mRNA associated with chemokine and rheumatoid arthritis
4) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.79 Pain Relevance 0.45
After injection of dsRNA, we observed a down-regulation of the homeostatic chemokine CCL21, which attracts CCR7+ cells, such as DCs and naïve T cells, to lymph nodes.
Negative_regulation (regulation) of homeostatic chemokine CCL21 in lymph nodes associated with chemokine
5) Confidence 0.20 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.32 Pain Relevance 0.22

General Comments

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