INT221083

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 1.48
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CES2) catabolic process (CES2)
Anatomy Link Frequency
lung 1
CES2 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 7 64.88 Quite High
Glutamate 6 36.48 Quite Low
lidocaine 6 5.00 Very Low Very Low Very Low
cocaine 6 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 9 98.68 Very High Very High Very High
Cancer 55 97.88 Very High Very High Very High
Vomiting 2 91.20 High High
Sunburn 3 90.48 High High
Non-small-cell Lung Cancer 27 74.08 Quite High
Small Cell Lung Cancer 32 72.40 Quite High
Small Cell Lung Carcinoma 7 56.68 Quite High
Hemangiosarcoma 1 51.76 Quite High
Photosensitivity Disorders 7 50.00 Quite Low
Bladder Cancer 1 46.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consequently, all 3 CES2 like genes are localized within 155 kb of DNA on chromosome 1 (Figure 3).
Localization (localized) of CES2
1) Confidence 0.80 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
As mentioned previously, the N-glycosylation site reported for human CES1 (79–81: NAT) is retained for the opossum CES1 (NTT) and CES2.1 (NAT) sequences, but is absent from other opossum and human CES gene products, whereas opossum CES1 (2), CES2.1 (4), CES2.2 (1) and CES2.3 (1) have other potential glycosylation sites (Figure 3).
Localization (retained) of CES2
2) Confidence 0.75 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Locations for Opossum CES1, CES2 and CES6 'Like' Genes on Chromosome 1
Localization (Locations) of CES2
3) Confidence 0.75 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Figure 2 and Table 2 show the amino acid sequence alignments, the predicted secondary structures and sequence identities for the predicted opossum CES1, multiple CES2Like and CES6Like proteins, as well as the six human CES gene products, previously described [16-26] (RS Holmes, J Glenn, JL VandeBerg & LA Cox: Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases, unpublished).
Localization (multiple) of CES2Like
4) Confidence 0.75 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Other key functional residues for human CES1 and CES2 have been retained by the opossum CES2 like enzymes, including the 'Z-site' (Gly356 for human CES1), which functions in cholesterol binding; the 'side door' residues at 424Val.Met425.Phe426; and the 'gate' residue 551Phe (for human CES1), both of which have either been retained or have undergone conservative substitution.
Localization (retained) of CES2
5) Confidence 0.75 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Other key functional residues for human CES1 and CES2 have been retained by the opossum CES2 like enzymes, including the 'Z-site' (Gly356 for human CES1), which functions in cholesterol binding; the 'side door' residues at 424Val.Met425.Phe426; and the 'gate' residue 551Phe (for human CES1), both of which have either been retained or have undergone conservative substitution.
Localization (retained) of CES2
6) Confidence 0.65 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
As it was important to establish if cellular localization of Ce6-PVP was also exhibited in human lung tumor, the CAM tumor xenograft was employed here.
Localization (localization) of Ce6 in lung associated with lung cancer and cancer
7) Confidence 0.02 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2212622 Disease Relevance 1.48 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox