INT221097

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 10.52
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Atp8a1)
Anatomy Link Frequency
liver 1
fibroblasts 1
bladder 1
T cells 1
Atp8a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 58 99.28 Very High Very High Very High
Potency 17 98.52 Very High Very High Very High
Inflammation 122 97.60 Very High Very High Very High
Lasting pain 12 97.08 Very High Very High Very High
rheumatoid arthritis 150 96.76 Very High Very High Very High
carbamazepine 2 96.50 Very High Very High Very High
Spinal cord 39 95.52 Very High Very High Very High
Arthritis 17 95.52 Very High Very High Very High
Thermal hyperalgesia 14 95.24 Very High Very High Very High
Bioavailability 27 94.92 High High
Disease Link Frequency Relevance Heat
Death 37 99.04 Very High Very High Very High
Liver Cancer 2 99.00 Very High Very High Very High
Cancer 422 98.68 Very High Very High Very High
Myeloid Leukemia 143 98.44 Very High Very High Very High
Myelodysplastic Syndromes 179 98.12 Very High Very High Very High
Disease 218 97.96 Very High Very High Very High
Apoptosis 118 97.84 Very High Very High Very High
INFLAMMATION 148 97.60 Very High Very High Very High
Pain 29 97.08 Very High Very High Very High
Rheumatoid Arthritis 153 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Valproic acid, which has been used as an antiepileptic drug for many years and still is used in this indication, has been shown to inhibit preferably class I HDACs in the high micromolar to millimolar range.
Negative_regulation (inhibit) of class I
1) Confidence 0.57 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.20 Pain Relevance 0.08
Up-regulation of HDACs by lipopolysaccharide (LPS) or use of some HDAC inhibitors (particularly inhibitors of class I HDACs) results in amplified expression of proinflammatory genes such as COX-2 [55].
Negative_regulation (inhibitors) of class I
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 1.23 Pain Relevance 0.47
We demonstrated recently that FK228, a specific class I HDAC inhibitor, prevents the in vivo proliferation of RASFs and ameliorates the pathological changes of autoantibody-mediated arthritis in mice [19].
Negative_regulation (inhibitor) of class I associated with arthritis
3) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.99 Pain Relevance 0.32
The difference between the gene expression profiles resulting from the inhibition of class I HDACs and those following the inhibition of class IIa HDACs is also of interest, in view of their different effect on thermal hyperalgesia.
Negative_regulation (inhibition) of class I associated with thermal hyperalgesia
4) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942827 Disease Relevance 0.81 Pain Relevance 0.81
Although structurally diverse, these compounds contain a benzamide moiety and are selective, potent inhibitors of class I HDACs.
Negative_regulation (inhibitors) of class I
5) Confidence 0.57 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.61 Pain Relevance 0.05
Because we studied a natural deficiency of ERAP2, our results suggest that the observed reduction in MHC class I levels is not transient and that BB-homozygotes likely have lower background levels of MHC presentation.
Negative_regulation (reduction) of class I
6) Confidence 0.42 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.45 Pain Relevance 0.04
Total or selective losses of HLA class I antigens (classified into seven HLA class I altered phenotypes) represent one of the main routes of tumor escape from immune surveillance in several malignancies including bladder cancer [57-60].
Negative_regulation (losses) of class I in bladder associated with cancer and bladder cancer
7) Confidence 0.42 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.49 Pain Relevance 0
Although in this system carbamazepine failed to show HDAC inhibition, in a subsequent report this drug induced histone H4 acetylation in the HepG2 liver carcinoma cell line and inhibited HDAC 3 and -7, which are representative of HDAC class I and II, respectively.
Negative_regulation (representative) of class I in liver associated with liver cancer and carbamazepine
8) Confidence 0.42 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.40 Pain Relevance 0.08
It is a more selective inhibitor of the class I HDACs, preferentially blocking HDACs 1 and 2 versus HDACs 4 and 6 [134] (Table 2).
Negative_regulation (inhibitor) of class I
9) Confidence 0.41 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.98 Pain Relevance 0
Finally, the class I hexose transporter inhibitor phloretin had no significant effect on urate transport (< 10% inhibition) when applied at a concentration of 1 mM, p > 0.05 (Figure 1C).


Negative_regulation (inhibitor) of class I
10) Confidence 0.41 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0 Pain Relevance 0
We have reported recently that FK228, an inhibitor of class I HDAC shows inhibitory effects on the proliferation of synovial fibroblasts from RA (RASFs) and ameliorates collagen antibody-induced pathology in mice [19].
Negative_regulation (inhibitor) of class I in fibroblasts associated with rheumatoid arthritis
11) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.09 Pain Relevance 0.38
We hypothesize that CNS infiltrating CD8 T cells are hyper-stimulated by the presence of excess VP2121–130 peptide antigen presented on Db class I molecules in the CNS.
Negative_regulation (presented) of class I in T cells associated with central nervous system
12) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0.28 Pain Relevance 0.37
In a recently published study by our research group, we demonstrated that HDAC Class I and II inhibitors such as TSA can induce death of tumor cell lines via apoptosis [63].
Negative_regulation (inhibitors) of Class I associated with cancer, apoptosis and death
13) Confidence 0.41 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 1.27 Pain Relevance 0
The sequence EIAY, located at amino acid positions 66, 67, 74, and 78 within the antigen recognition sites (ARS), was found in 12 animals classified as resistant, and 10 of them also displayed class I BoLA-A8 specificity.
Negative_regulation (displayed) of class I
14) Confidence 0.41 Published 2008 Journal Mamm Genome Section Body Doc Link PMC2323435 Disease Relevance 0.14 Pain Relevance 0
These drugs inhibit both class I and IIa HDACs, but usually show low potency due to the inability to make significant contact with the catalytic pocket of HDACs [103] (Table 2).
Negative_regulation (inhibit) of class I associated with potency
15) Confidence 0.41 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.58 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox