INT2211

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Context Info
Confidence 0.59
First Reported 1978
Last Reported 2010
Negated 3
Speculated 5
Reported most in Abstract
Documents 267
Total Number 274
Disease Relevance 66.51
Pain Relevance 200.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
brain 16
neurons 12
spinal 7
dorsal horn 7
striatum 6
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 3978 100.00 Very High Very High Very High
Glutamate 1301 100.00 Very High Very High Very High
Dopamine 888 100.00 Very High Very High Very High
antagonist 492 100.00 Very High Very High Very High
Serotonin 255 100.00 Very High Very High Very High
tetrodotoxin 122 100.00 Very High Very High Very High
substance P 79 100.00 Very High Very High Very High
Enkephalin 73 100.00 Very High Very High Very High
Potency 23 100.00 Very High Very High Very High
Versed 14 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sleep Disorders 219 100.00 Very High Very High Very High
Respiratory Paralysis 10 100.00 Very High Very High Very High
Stress 112 99.96 Very High Very High Very High
Injury 216 99.82 Very High Very High Very High
Disease 147 99.82 Very High Very High Very High
Nervous System Injury 773 99.74 Very High Very High Very High
Urological Neuroanatomy 104 99.68 Very High Very High Very High
Neuropathic Pain 280 99.52 Very High Very High Very High
Pain 172 99.52 Very High Very High Very High
Manic Depressive Disorder 85 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, gabapentin also decreased spinal reflexes in spinalized rats depleted of spinal GABA with semicarbazide, an inhibitor of the GABA-synthesizing enzyme.
Negative_regulation (inhibitor) of GABA-synthesizing enzyme in spinal associated with gaba and gabapentin
1) Confidence 0.59 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14978351 Disease Relevance 0 Pain Relevance 0.99
Depakine, the inhibitor of alpha-ketoglutarate-GABA-transaminase, as well as GABA itself administered in high doses (GABA-positive actions) make morphine analgesia more pronounced and longer.
Negative_regulation (inhibitor) of alpha-ketoglutarate-GABA-transaminase associated with gaba, analgesia and morphine
2) Confidence 0.58 Published 1979 Journal Biull Eksp Biol Med Section Abstract Doc Link 380685 Disease Relevance 0 Pain Relevance 1.31
Pretreatment of gamma-vinyl GABA (GVG), an irreversible GABA transaminase inhibitor, significantly attenuated the heroin-induced BOLD signal changes.
Negative_regulation (inhibitor) of GABA transaminase associated with gaba
3) Confidence 0.58 Published 2002 Journal Magn Reson Med Section Abstract Doc Link 12417998 Disease Relevance 0 Pain Relevance 0.84
It is shown that the stress effect is accompanied by the GABA level increase and GABA-transaminase inhibition with a simultaneous rise of the succinate dehydrogenase and glutamate dehydrogenase activity.
Negative_regulation (inhibition) of GABA-transaminase associated with stress, glutamate and gaba
4) Confidence 0.57 Published 1983 Journal Ukr. Biokhim. Zh. Section Abstract Doc Link 6686357 Disease Relevance 0.61 Pain Relevance 0.62
Aminooxyacetic acid, an inhibitor of GABA transaminase, potentiated the effect of GABA.
Negative_regulation (inhibitor) of GABA associated with gaba
5) Confidence 0.57 Published 1983 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 6668764 Disease Relevance 0 Pain Relevance 0.86
Vigabatrin, a GABA-transaminase inhibitor, has been associated with bilateral concentric visual field loss, electrophysiological changes, central visual function deficits including reduced contrast sensitivity and abnormal colour perception, and morphological alterations of the fundus and retina.
Negative_regulation (inhibitor) of GABA-transaminase in retina associated with gaba
6) Confidence 0.57 Published 2004 Journal Seizure Section Abstract Doc Link 15129841 Disease Relevance 0.34 Pain Relevance 0.36
Inhibition of GABA-transaminase (GABA-T) by aminooxyacetic acid (AOAA) in other compartments of the brain would result in an inhibition of the stimulated GABA-release via feedback on autoreceptors and therefore suppress the DPA-evoked behaviour.
Negative_regulation (Inhibition) of GABA-T in brain associated with gaba
7) Confidence 0.57 Published 1983 Journal Life Sci. Section Abstract Doc Link 6420629 Disease Relevance 0.06 Pain Relevance 0.88
Inhibition of GABA-T by gabapentin was weak (33%).
Negative_regulation (Inhibition) of GABA-T associated with gaba and gabapentin
8) Confidence 0.57 Published 1995 Journal Epilepsy Res. Section Abstract Doc Link 8565962 Disease Relevance 0 Pain Relevance 1.62
AOAA and GAG were found to be strong inhibitors of GABA-T whereas the other two compounds were less efficient in the used doses.
Negative_regulation (inhibitors) of GABA-T associated with gaba
9) Confidence 0.57 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3933514 Disease Relevance 0.19 Pain Relevance 0.85
Four inhibitors of gamma-aminobutyric acid transaminase (GABA-T) were investigated together with respect to their effects on hole-board exploration and temperature and the relation with effects on quasi-morphine-abstinence behaviour induced by dipropylacetate (DPA) in rats.
Negative_regulation (inhibitors) of GABA-T associated with gaba and morphine
10) Confidence 0.57 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3933514 Disease Relevance 0 Pain Relevance 0.40
Inhibition of GABA-transaminase (GABA-T) by aminooxyacetic acid (AOAA) in other compartments of the brain would result in an inhibition of the stimulated GABA-release via feedback on autoreceptors and therefore suppress the DPA-evoked behaviour.
Negative_regulation (Inhibition) of GABA-transaminase in brain associated with gaba
11) Confidence 0.56 Published 1983 Journal Life Sci. Section Abstract Doc Link 6420629 Disease Relevance 0.06 Pain Relevance 0.88
Inhibition of GABA-transaminase (GABA-T) by aminooxyacetic acid (AOAA) in other compartments of the brain would result in an inhibition of the stimulated GABA-release via feedback on autoreceptors and therefore suppress the DPA-evoked behaviour.
Negative_regulation (inhibition) of GABA-release in brain associated with gaba
12) Confidence 0.56 Published 1983 Journal Life Sci. Section Abstract Doc Link 6420629 Disease Relevance 0.07 Pain Relevance 0.98
Effects of gamma-vinyl-GABA (GVG), an antiepileptic drug that inhibits GABA transaminase and increases extracellular GABA concentrations in the brain, were investigated on the morphine abstinence syndrome (AS) in male Wistar rats.
Negative_regulation (inhibits) of GABA transaminase in brain associated with gaba, syndrome, abstinence syndrome and morphine
13) Confidence 0.55 Published 1998 Journal Pharmacol. Res. Section Abstract Doc Link 9697154 Disease Relevance 0.37 Pain Relevance 1.03
The drug intake in a single doze of 10 mg/kg is accompanied by a decrease in the levels of dopamine, serotonin, and GABA in the cerebellum.
Negative_regulation (decrease) of GABA in cerebellum associated with gaba, dopamine and serotonin
14) Confidence 0.51 Published 2009 Journal Eksp Klin Farmakol Section Abstract Doc Link 19928568 Disease Relevance 0.10 Pain Relevance 0.63
None of the drugs facilitating GABA-mediated transmission, including uptake blockers, GABA-transaminase inhibitors and agonists of the A-type receptor, was able to reduce the glutamate release, seizures or neuronal damage produced by 4-aminopyridine.
Negative_regulation (inhibitors) of GABA-transaminase in neuronal associated with glutamate, gaba, convulsion and agonist
15) Confidence 0.46 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113304 Disease Relevance 0.51 Pain Relevance 0.75
Vigabatrin (10 nmol), a selective GABA-transaminase inhibitor which increases endogenous GABA level, abolished CSAR, and decreased baseline RSNA, MAP and HR.
Negative_regulation (inhibitor) of GABA-transaminase associated with gaba
16) Confidence 0.45 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18554298 Disease Relevance 0 Pain Relevance 0.92
Application of gamma-vinyl GABA (100 mg/kg), an irreversible GABA-transaminase inhibitor, failed to block opiate actions in the heroin-SA rats.
Negative_regulation (inhibitor) of GABA-transaminase associated with gaba and opiate
17) Confidence 0.43 Published 2004 Journal Magn Reson Med Section Abstract Doc Link 15236373 Disease Relevance 0 Pain Relevance 0.66
Ketamine-induced rotation: interaction with GABA-transaminase inhibitors and picrotoxin.
Negative_regulation (inhibitors) of GABA-transaminase associated with gaba and ketamine
18) Confidence 0.43 Published 1979 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 575219 Disease Relevance 0 Pain Relevance 0.45
Significant increases in locomotion occurred when GABA (300 micrograms) was injected along with the inhibitor of GABA-transaminase, d,l-gamma-vinyl-GABA (GVG; 5 micrograms) and the inhibitor of the uptake of GABA, 1-2,4-diaminobutyric acid (DABA; 5 micrograms).
Negative_regulation (inhibitor) of GABA-transaminase associated with gaba
19) Confidence 0.43 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3216960 Disease Relevance 0.06 Pain Relevance 0.69
GABA(B2) receptor subunit mRNA decreases in the thalamus of monoarthritic animals.
Negative_regulation (decreases) of GABA in thalamus associated with gaba and thalamus
20) Confidence 0.43 Published 2006 Journal Brain Res. Bull. Section Title Doc Link 17113954 Disease Relevance 0.10 Pain Relevance 0.67

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