INT221108

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.76
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc11a1) plasma membrane (Slc11a1) lysosome (Slc11a1)
Anatomy Link Frequency
bladder 3
Slc11a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 156 99.92 Very High Very High Very High
Inflammatory response 17 98.08 Very High Very High Very High
cytokine 64 86.88 High High
Hippocampus 15 50.84 Quite High
Inflammatory stimuli 4 42.24 Quite Low
IPN 2 40.56 Quite Low
imagery 12 5.00 Very Low Very Low Very Low
interstitial cystitis 7 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Demyelination 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bladder Cancer 67 100.00 Very High Very High Very High
Cancer 111 99.98 Very High Very High Very High
INFLAMMATION 177 99.92 Very High Very High Very High
Sprains And Strains 16 97.56 Very High Very High Very High
Mycobacterial Infection 18 94.40 High High
Bordatella Infection 4 93.36 High High
Infection 103 82.48 Quite High
Congenital Anomalies 43 82.48 Quite High
Death 16 79.12 Quite High
Cyst 60 76.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These groups of genes seem to be a specific bladder response to BCG therapy since they were not represented in the control- and LPS-treated SSHs [25].
Negative_regulation (response) of BCG in bladder
1) Confidence 0.33 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.14 Pain Relevance 0.03
NRAMP1 is the human ortholog of Bcg gene [21], discovered in an animal model of orthotopic murine bladder tumors, and responsible for tumor responsiveness to BCG [23].
Negative_regulation (responsiveness) of BCG in bladder associated with cancer and bladder cancer
2) Confidence 0.33 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.62 Pain Relevance 0
Deficiency in IL4, IL13 and NRAMP are not sufficient to abrogate this inflammatory process.
Negative_regulation (Deficiency) of NRAMP associated with inflammation
3) Confidence 0.33 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.19 Pain Relevance 0.31
Therefore, we propose evaluation of the effectiveness on tumor reduction of rBCG-S1PT, compared to BCG and PBS; and evaluation of the immune response profile focusing on TNF-?
Negative_regulation (reduction) of rBCG associated with cancer
4) Confidence 0.19 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2647907 Disease Relevance 0.59 Pain Relevance 0.06
The data of this study indicate a significant reduction of bladder tumor volume in the rBCG group, compared to BCG and PBS, which may indicate that rBCG could be a useful substitute for wild-type BCG and suggest that the potential modulation between TNF-?
Negative_regulation (reduction) of rBCG in bladder associated with bladder cancer
5) Confidence 0.16 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2647907 Disease Relevance 0.56 Pain Relevance 0.16
In addition to limiting BCG activity, this group of GTPases is part of the inflammatory response.
Negative_regulation (limiting) of BCG associated with inflammatory response
6) Confidence 0.09 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.65 Pain Relevance 0.14

General Comments

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