INT221113

Context Info Confidence 0.19 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.37 Pain Relevance 0

transport (Slc11a1) plasma membrane (Slc11a1) lysosome (Slc11a1)

Anatomy Link Frequency bladders 1 Slc11a1 (Mus musculus) Upk1b (Mus musculus)

Pain Link Frequency Relevance Heat agonist 1 43.44 cytokine 9 5.00 Inflammation 9 5.00 Inflammatory response 3 5.00 interstitial cystitis 2 5.00 Inflammatory stimuli 1 5.00

Disease Link Frequency Relevance Heat Cystitis 2 84.12 Infection 11 79.28 Targeted Disruption 1 78.60 Bladder Cancer 10 27.48 Cancer 10 19.08 INFLAMMATION 13 5.00 Mycobacterial Infection 7 5.00 Interstitial Cystitis 2 5.00 Disease 2 5.00 Carcinoma 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In our current study, we found that UPK2 and UPK3a, two single membrane spanins, but not UPK1a and UPK1b, two tetraspanins, are down-regulated in chronically treated bladders by BCG.

BCG Negative_regulation (regulated) of UPK1b in bladders

1) Confidence 0.19 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.37 Pain Relevance 0

General Comments

This test has worked.