INT22112

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2011
Negated 10
Speculated 4
Reported most in Abstract
Documents 164
Total Number 167
Disease Relevance 115.66
Pain Relevance 52.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophages 33
lung 11
heart 6
mononuclear cell 6
T cells 6
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2480 100.00 Very High Very High Very High
cytokine 1781 100.00 Very High Very High Very High
Etanercept 294 100.00 Very High Very High Very High
Inflammatory mediators 93 100.00 Very High Very High Very High
ischemia 50 100.00 Very High Very High Very High
substance P 142 99.98 Very High Very High Very High
Morphine 45 99.92 Very High Very High Very High
Central nervous system 127 99.86 Very High Very High Very High
dexamethasone 19 99.84 Very High Very High Very High
dorsal root ganglion 6 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2583 100.00 Very High Very High Very High
Obesity 1087 100.00 Very High Very High Very High
Cancer 617 100.00 Very High Very High Very High
Necrosis 243 100.00 Very High Very High Very High
Death 215 100.00 Very High Very High Very High
Nicotine Addiction 207 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 148 100.00 Very High Very High Very High
Heart Rate Under Development 39 100.00 Very High Very High Very High
Brain Hemorrhage 19 100.00 Very High Very High Very High
Mycobacterial Infection 668 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results show that minimal mechanical trauma is sufficient to induce significant TNF-alpha release in the skin.
Positive_regulation (induce) of Localization (release) of TNF-alpha in skin associated with injury
1) Confidence 0.70 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 19931249 Disease Relevance 0.10 Pain Relevance 0.37
The stimuli inducing TNF-alpha release in humans and the time course of this release are largely unknown.
Positive_regulation (inducing) of Localization (release) of TNF-alpha
2) Confidence 0.70 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 19931249 Disease Relevance 0.49 Pain Relevance 0.50
A bell-shaped dose-response curve was observed for the priming effect of morphine; maximal enhancement of TNF-alpha release (310 +/- 15% of control) was detected at a concentration of 10(-10) M morphine.
Positive_regulation (enhancement) of Localization (release) of TNF-alpha associated with morphine
3) Confidence 0.70 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8169825 Disease Relevance 0.39 Pain Relevance 1.00
The clinical and pathologic manifestations of macrophage activation syndrome (MAS) are thought to result from the activation and uncontrolled proliferation of T-lymphocytes and well-differentiated macrophages, which leads to an unrestricted release of inflammatory cytokines, such as TNF-?
Positive_regulation (leads) of Localization (release) of TNF in macrophage associated with inflammation, macrophage activation syndrome and cytokine
4) Confidence 0.67 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012271 Disease Relevance 1.25 Pain Relevance 0.29
It appears to lead to a reduction of contact hypersensitivity by inducing mast cells to degranulate and thus release tumor necrosis factor alpha (TNF-alpha) and, most likely, interleukin (IL)-10.
Positive_regulation (inducing) of Localization (release) of TNF-alpha in mast cells associated with necrosis, cancer and contact dermatitis
5) Confidence 0.67 Published 2002 Journal Methods Section Abstract Doc Link 12231193 Disease Relevance 0.54 Pain Relevance 0.46
The results of our study are supported by the findings, that bacteria, lipopolysaccharide (endotoxin) and other factors are known to cause an increase in the release of a number of cytokines including TNF-?
Positive_regulation (increase) of Localization (release) of TNF associated with cytokine
6) Confidence 0.67 Published 2006 Journal BMC Surg Section Body Doc Link PMC1712352 Disease Relevance 0.93 Pain Relevance 0.15
To determine the role of cytokines in ECC-induced insulin resistance, venous blood samples were obtained before (control) and 24 h after ECC to evaluate ex vivo endotoxin-induced mononuclear cell secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta.
Positive_regulation (induced) of Localization (secretion) of TNF in mononuclear cell associated with necrosis, cancer, insulin resistance and cytokine
7) Confidence 0.67 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.59 Pain Relevance 0.05
Evidence that implicates TNF in the underlying pathology of multiple sclerosis (MS) includes: the observation that at autopsy MS patients have elevated TNF levels at the site of active MS lesions [70]; reports that CSF and serum TNF levels in individuals with MS are elevated compared to unaffected individuals and TNF levels correlate to the severity of the lesions [72,123,124]; and evidence that peripheral blood mononuclear cells from MS patients just prior to symptom exacerbation have increased TNF secretion after stimulation compared to cells form the same patients during remission [73,125].
Positive_regulation (increased) of Localization (secretion) of TNF in mononuclear cells associated with multiple sclerosis
8) Confidence 0.61 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 1.34 Pain Relevance 0.47
The results show that extensive myocardial infarction induces the release of the monocyte/macrophage-derived polypeptide hormone TNF into circulation.
Positive_regulation (induces) of Localization (release) of TNF in macrophage associated with myocardial infarction
9) Confidence 0.61 Published 1989 Journal J. Intern. Med. Section Abstract Doc Link 2732671 Disease Relevance 1.02 Pain Relevance 0.17
These papers predicted that the nature of the malarial product that triggers illness could be defined through its ability to induce release of TNF from mammalian cells.
Positive_regulation (induce) of Localization (release) of TNF
10) Confidence 0.54 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 0.35 Pain Relevance 0.04
Microglial cell cultures did not release TNF-alpha when incubated with morphine alone; however, an enhanced (P < .01) release of TNF-alpha was observed when cultures were first primed with morphine for 24 h and then stimulated with lipopolysaccharide.
Positive_regulation (enhanced) of Localization (release) of TNF-alpha in Microglial cell associated with morphine
11) Confidence 0.50 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8169825 Disease Relevance 0.41 Pain Relevance 0.88
Pretreatment of PBMC cultures for 1 h with naloxone blocked (P < 0.05) the inhibitory effect of morphine on the release of TNF upon stimulation with phytohemagglutinin, but not with lipopolysaccharide, suggesting the involvement of an opioid receptor.
Positive_regulation (stimulation) of Localization (release) of TNF in PBMC associated with narcan, opioid receptor and morphine
12) Confidence 0.50 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8389331 Disease Relevance 0.15 Pain Relevance 0.92
We use quantitative PCR for TNF-?
Positive_regulation (quantitative) of Localization (use) of TNF
13) Confidence 0.50 Published 2010 Journal J Vis Exp Section Abstract Doc Link 20834222 Disease Relevance 0 Pain Relevance 0.29
The Salix extract inhibited the LPS-induced release of tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 with IC50-values of 180.0, 33.0 and 86.0 microg/ml, respectively.
Positive_regulation (-) of Localization (release) of tumor necrosis factor-alpha associated with necrosis and cancer
14) Confidence 0.49 Published 2004 Journal Phytomedicine Section Abstract Doc Link 15070163 Disease Relevance 0.42 Pain Relevance 0.26
Histamine, PGD(2) and TNFalpha release, immunologically induced by canine anti-IgE, were significantly inhibited in the presence of PEA.
Positive_regulation (induced) of Localization (release) of TNFalpha
15) Confidence 0.49 Published 2010 Journal Vet. Immunol. Immunopathol. Section Abstract Doc Link 19625089 Disease Relevance 0.41 Pain Relevance 0.18
Dramatic increases in the number of PP CXCL11+ T cells, PP and LP CXCR3+ T cells and PP TNF-?
Positive_regulation (increases) of Localization (number) of TNF in T cells
16) Confidence 0.49 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.53 Pain Relevance 0.15
In conclusion, our study findings suggest that smoking may induce inflammation measured as TNF-?
Spec (may) Positive_regulation (induce) of Localization (measured) of TNF associated with nicotine addiction and inflammation
17) Confidence 0.49 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 1.23 Pain Relevance 0.14
Besides neutrophils, lung macrophages are believed to play an important role in COPD, in part by their ability to release TNF-?
Positive_regulation (ability) of Localization (release) of TNF in lung associated with pulmonary disease
18) Confidence 0.49 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.38 Pain Relevance 0.11
Similar effects are induced on dendritic cells, mediated, in part, by neutrophil release of TNF?
Positive_regulation (induced) of Localization (release) of TNF in neutrophil
19) Confidence 0.49 Published 2007 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC1904449 Disease Relevance 0.62 Pain Relevance 0.21
After 72 h cells were restimulated for 1 h with PMA (10 ng/ml) and ionomycin (1 µg/ml) (both from Sigma Aldrich) and the secreted TNF-?
Positive_regulation (restimulated) of Localization (secreted) of TNF
20) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.19

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