INT221127

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 12
Disease Relevance 4.70
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
medial 1
IGKV1-22 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 616 99.52 Very High Very High Very High
iatrogenic 11 94.60 High High
ketamine 55 94.28 High High
deep brain stimulation 66 94.16 High High
Anterior cingulate 66 85.88 High High
amygdala 253 84.96 Quite High
Nucleus accumbens 154 76.56 Quite High
Hippocampus 22 74.04 Quite High
imagery 22 73.76 Quite High
positron emission tomography 11 72.16 Quite High
Disease Link Frequency Relevance Heat
Repression 440 99.96 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 88 99.68 Very High Very High Very High
Depression 792 99.52 Very High Very High Very High
Reprotox - General 3 253 98.20 Very High Very High Very High
Aggression 66 92.04 High High
Schizophrenia 11 81.36 Quite High
Manic Depressive Disorder 88 70.64 Quite High
Unconsciousness 616 63.40 Quite High
Stress 11 49.80 Quite Low
Drug Induced Neurotoxicity 11 48.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results show a small, but statistically significant improvement of pmra over bm25 (both default and optimized), but no significant difference between optimized and default bm25.
Positive_regulation (improvement) of bm25
1) Confidence 0.17 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC2212667 Disease Relevance 0 Pain Relevance 0
Impassioned behaviours deemed dangerous to the ego in the context of its environment may be denied expression by activating Cg25 and the DMN.
Positive_regulation (activating) of Cg25
2) Confidence 0.11 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.16 Pain Relevance 0.23
Integrating this hypothesis into a model of depression, we can postulate that activating Cg25 and the DMN controls the full expression of affective, mnemonic and motivational behaviours promulgated by visceromotor centres.
Positive_regulation (activating) of Cg25 associated with depression
3) Confidence 0.11 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.16 Pain Relevance 0.22
For example, it is possible that activation of Cg25 supports activation of the DMN and deactivation of Cg25 supports deactivation of the DMN and activation of the ON.
Positive_regulation (activation) of Cg25
4) Confidence 0.11 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.48 Pain Relevance 0.13
Are we to assume that electrical stimulation of Cg25 removes both the physiological and psychological causes of depression?
Positive_regulation (stimulation) of Cg25 associated with depression
5) Confidence 0.10 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.85 Pain Relevance 0.15
The 'something...taken away' described in these accounts is consistent with the idea of a release from repression (deactivation of Cg25) and a return to object cathexis (DLPFC activation).
Positive_regulation (deactivation) of Cg25 associated with repression
6) Confidence 0.08 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.10 Pain Relevance 0.06
Interestingly, sudden and dramatic deactivations of Cg25 and functionally related regions of the vmPFC and OFC have recently been recorded after intravenous infusion of the dissociative hallucinogen ketamine in healthy human volunteers [121].
Positive_regulation (deactivations) of Cg25 associated with ketamine
7) Confidence 0.08 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.15 Pain Relevance 0.11
For example, it is possible that activation of Cg25 supports activation of the DMN and deactivation of Cg25 supports deactivation of the DMN and activation of the ON.
Positive_regulation (deactivation) of Cg25
8) Confidence 0.08 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.48 Pain Relevance 0.12
Hyperactivity and electrical stimulation of Cg25
Positive_regulation (stimulation) of Cg25 associated with attention deficit hyperactivity disorder
9) Confidence 0.08 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.49 Pain Relevance 0.23
The preliminary results of chronic bilateral high frequency stimulation of Cg25 in six patients suffering from severe treatment-resistant depression were reported by Mayberg and colleagues [51].
Positive_regulation (stimulation) of Cg25 associated with depression
10) Confidence 0.08 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.53 Pain Relevance 0.28
It has been inferred in this paper that the sudden lifting of negative affect upon stimulation of Cg25 is consistent with the idea of a release of libido for object cathexis after it has been pathologically 'dammed up' behind a central repressing force.
Positive_regulation (stimulation) of Cg25 associated with reprotox - general 3
11) Confidence 0.08 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.91 Pain Relevance 0.36
We would also predict that patients undergoing Cg25 stimulation would be more susceptible to temporal lobe phenomena (such as déjà vu) as a result of diminished inhibitory control over excitatory medial temporal structures.
Positive_regulation (stimulation) of Cg25 in medial
12) Confidence 0.07 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.38 Pain Relevance 0.04

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