INT221131

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Context Info
Confidence 0.80
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 13.82
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2) plasma membrane (Tlr2) intracellular (Tlr2)
cytoplasm (Tlr2)
Anatomy Link Frequency
myocardium 1
immune cells 1
kidney 1
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 13 100.00 Very High Very High Very High
cytokine 154 99.98 Very High Very High Very High
Inflammatory response 38 95.52 Very High Very High Very High
Inflammation 229 88.48 High High
imagery 7 65.84 Quite High
fibrosis 103 65.44 Quite High
Angina 18 65.28 Quite High
rheumatoid arthritis 3 59.12 Quite High
metalloproteinase 48 53.12 Quite High
antagonist 10 50.80 Quite High
Disease Link Frequency Relevance Heat
Hydronephrosis 231 100.00 Very High Very High Very High
Necrosis 15 99.86 Very High Very High Very High
Acne 164 99.78 Very High Very High Very High
Cancer 1111 99.58 Very High Very High Very High
Shock 8 99.32 Very High Very High Very High
Stress 29 98.00 Very High Very High Very High
Glioma 115 97.96 Very High Very High Very High
Ureteral Obstruction 108 97.92 Very High Very High Very High
Brain Tumor 236 96.40 Very High Very High Very High
INFLAMMATION 264 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The intracellular localization of TLR2 is consistent with data demonstrating that upon stimulation by specific ligands, TLR2 receptor clusters are targeted to the Golgi apparatus [35].
Localization (localization) of TLR2 associated with hydronephrosis
1) Confidence 0.80 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.70 Pain Relevance 0.06
We hypothesized that endogenous TLR2 ligands would also be released from GL26 cells treated with Ad-TK + GCV.
Localization (released) of TLR2
2) Confidence 0.79 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.93 Pain Relevance 0.05
Thus, both Flt3L-induced recruitment of immune cells to the brain and TK-dependent release of the TLR2 agonist HMGB1 are necessary for tumor elimination; together, they are sufficient to induce the regression of a large intracranial glioma and melanoma tumors.
Localization (release) of TLR2 in immune cells associated with melanoma, cancer, agonist and glioma
3) Confidence 0.79 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.61 Pain Relevance 0.05
mouse IgG1-AP (Southern Biotech) for TLR2, goat ?
Localization (goat) of TLR2 associated with hydronephrosis
4) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 0.72 Pain Relevance 0.06
To evaluate the influence of fibrinogenesis at different stages on the expression and localization of TLR2 we next measured the amount of mRNA and protein in UUO-injured kidney of TLR2+/+ mice at several time points.
Localization (localization) of TLR2 in kidney associated with ureteral obstruction
5) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.02 Pain Relevance 0.07
Therefore, we hypothesized that HMGB1 could be an endogenous TLR2 ligand released from TK + GCV treated GL26 cells.
Localization (released) of TLR2
6) Confidence 0.69 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.02 Pain Relevance 0.03
We hypothesized that tumor cell necrosis could release endogenous TLR2 ligands and thus activate DC.
Localization (release) of TLR2 associated with necrosis and cancer
7) Confidence 0.69 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.37 Pain Relevance 0.06
We identified high-mobility-group box 1 (HMGB1) as an endogenous TLR2 agonist that was released from dying tumor cells, both in vitro and in vivo in response to several tumor cell killing approaches, i.e., adenoviral vector (Ad)-TK (+GCV), radiation, and temozolomide.
Localization (released) of TLR2 associated with cancer and agonist
8) Confidence 0.69 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.07 Pain Relevance 0.08
Immunohistochemistry for TLR2 and TLR4
Localization (Immunohistochemistry) of TLR2
9) Confidence 0.63 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.14 Pain Relevance 0
Asea et al. [28] have reported that the release of HSP70, as a common endogenous ligand of both TLR2 and TLR4, in response to ischaemic myocardium may activate TLR2 and TLR4 signalling in circulating monocytes.
Localization (ligand) of TLR2 in myocardium
10) Confidence 0.63 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.25 Pain Relevance 0.06
Blocking TLR2 reversed B16 cell-induced inhibitory immune microenvironment
Localization (Blocking) of TLR2
11) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.48 Pain Relevance 0.04
TLR2 and TLR4 immunostaining is frequently co-localized with NF-?
Localization (localized) of TLR2
12) Confidence 0.59 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.92 Pain Relevance 0.25
Despite this reduction, cytokine release by TLR2?
Localization (release) of TLR2 associated with cytokine
13) Confidence 0.38 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.05 Pain Relevance 0.12
and IL-6 was inhibited in TLR4- and TLR2-deficient BMDCs, indicating that both TLR2 and TLR4 participate in the response to H. pylori LPS.
Localization (participate) of TLR2
14) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877707 Disease Relevance 0.12 Pain Relevance 0
RI interaction with OmpA enhances the expression of TLR2, which in turn can be utilized by the bacteria as a receptor to modulate the efficiency of phagosome formation.
Localization (utilized) of TLR2
15) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987830 Disease Relevance 0.27 Pain Relevance 0.03
It has been shown that sebocytes expressed Toll-like receptor 2 (TLR2) and secreted cytokine IL-8 once they were stimulated with P. acnes [15].
Localization (secreted) of TLR2 associated with acne and cytokine
16) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 1.07 Pain Relevance 0.16
It has been shown that sebocytes expressed Toll-like receptor 2 (TLR2) and secreted cytokine IL-8 once they were stimulated with P. acnes [15].
Localization (secreted) of Toll-like receptor 2 associated with acne and cytokine
17) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 1.07 Pain Relevance 0.16

General Comments

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