INT221166

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.09
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Flna) plasma membrane (Flna) nucleus (Flna)
transcription factor binding (Flna) biological_process (Flna) cytoplasm (Flna)
Anatomy Link Frequency
brain 2
Flna (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 175 100.00 Very High Very High Very High
Morphine 111 100.00 Very High Very High Very High
mu opioid receptor 191 99.80 Very High Very High Very High
opiate 6 89.88 High High
tolerance 33 84.96 Quite High
Opioid 92 84.56 Quite High
agonist 1 71.20 Quite High
addiction 31 37.76 Quite Low
antagonist 21 5.00 Very Low Very Low Very Low
analgesia 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vibrio Infection 1 87.40 High High
Injury 2 13.20 Low Low
Opiate Addiction 4 5.00 Very Low Very Low Very Low
Drug Dependence 3 5.00 Very Low Very Low Very Low
Skin Cancer 3 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Bordatella Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, although we observed FLNA in MOR signalplexes containing Go proteins in native brain tissue, the prior data in co-transfected cells indicates that FLNA is not required for the native coupling state of MOR; in fact, its absence actually enhances MOR function [15].
Neg (not) Positive_regulation (required) of FLNA in brain associated with mu opioid receptor
1) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0.09 Pain Relevance 1.09
To measure the MOR-mediated increase in cAMP production, brain slices were incubated with Kreb's-Ringer (basal), 100 µM morphine and/or co-treatment with 100 pM NLX, NTX or 10 µM VAKGL (FLNA2561–2565 ) for 5, 15 and 60 min in the presence of 100 µM phosphodiesterase inhibitor, IBMX.
Positive_regulation (increase) of FLNA2561 in brain associated with narcan, mu opioid receptor and morphine
2) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 0.61

General Comments

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