INT221168

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2008
Negated 3
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.05
Pain Relevance 4.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Flna) plasma membrane (Flna) nucleus (Flna)
transcription factor binding (Flna) biological_process (Flna) cytoplasm (Flna)
Flna (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 282 100.00 Very High Very High Very High
narcan 324 97.04 Very High Very High Very High
addiction 42 90.20 High High
tolerance 60 89.60 High High
Morphine 105 87.28 High High
Spinal cord 9 83.44 Quite High
analgesia 30 75.60 Quite High
Opioid 150 74.96 Quite High
agonist 3 73.36 Quite High
antagonist 48 68.08 Quite High
Disease Link Frequency Relevance Heat
Vibrio Infection 3 53.12 Quite High
Skin Cancer 9 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 3 5.00 Very Low Very Low Very Low
Drug Dependence 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MOR may subsequently release from both its native G protein and from FLNA itself leading to association with Gs without FLNA in the complex.
Neg (without) Localization (release) of FLNA associated with mu opioid receptor
1) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0.05 Pain Relevance 1.46
MOR may subsequently release from both its native G protein and from FLNA itself leading to association with Gs without FLNA in the complex.
Neg (without) Localization (release) of FLNA associated with mu opioid receptor
2) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.43
Rather than desensitization, Onoprishvili et al. actually noted enhanced inhibition by DAMGO of cAMP accumulation in cells lacking FLNA [15], a finding that also agrees with the idea that in signaling complexes that do not contain FLNA, MOR does not release from its Gi/o protein to interact with Gs.
Neg (not) Localization (release) of FLNA associated with mu opioid receptor
3) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.16

General Comments

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