INT221173

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.13
Pain Relevance 8.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Flna) plasma membrane (Flna) nucleus (Flna)
transcription factor binding (Flna) biological_process (Flna) cytoplasm (Flna)
Flna (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 573 100.00 Very High Very High Very High
narcan 525 99.86 Very High Very High Very High
Morphine 333 99.24 Very High Very High Very High
tolerance 99 98.00 Very High Very High Very High
addiction 93 97.56 Very High Very High Very High
opiate 18 95.96 Very High Very High Very High
Opioid 276 91.88 High High
analgesia 39 90.32 High High
Analgesic 24 88.08 High High
antagonist 63 87.00 High High
Disease Link Frequency Relevance Heat
Drug Dependence 9 73.36 Quite High
Vibrio Infection 3 60.24 Quite High
Pain 3 36.32 Quite Low
Opiate Addiction 12 5.00 Very Low Very Low Very Low
Skin Cancer 9 5.00 Very Low Very Low Very Low
Decapitation 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Bordatella Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By binding to FLNA, NLX and its analogs prevent this altered MOR–FLNA interaction, thereby preventing the release from the complexes and the resultant altered coupling.
Negative_regulation (prevent) of MOR-FLNA Neg (prevent) Binding (interaction) of associated with mu opioid receptor and narcan
1) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0.07 Pain Relevance 1.85
Our findings suggest that FLNA interacts with ultra-low-dose NLX and naltrexone to prevent chronic morphine-induced MOR–Gs coupling, possibly by preventing a critical MOR–FLNA interaction.
Negative_regulation (preventing) of MOR-FLNA Binding (interaction) of associated with mu opioid receptor, narcan and morphine
2) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.29
By binding to FLNA, NLX could block this particular MOR–FLNA interaction and stabilize the MOR-FLNA-G protein complexes, thereby reducing the morphine-induced release of MORs and their subsequent coupling with Gs in response to receptor stimulation.
Negative_regulation (block) of MOR-FLNA Binding (interaction) of associated with mu opioid receptor, narcan and morphine
3) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0.06 Pain Relevance 1.44
NLX and NTX presumably prevent the MOR–FLNA interaction by binding to their VAKGL binding site on FLNA, and this binding site on FLNA does appear be the approximate site on this protein that interacts with MOR.
Negative_regulation (prevent) of FLNA Neg (prevent) Binding (interaction) of associated with mu opioid receptor and narcan
4) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.23
While blocking the MOR–FLNA association, at least via ultra-low-dose NLX/NTX, diminishes tolerance, dependence and the rewarding effects of opiates, preserving or enhancing MOR's association with spinophilin appears to similarly modify these opioid effects.
Negative_regulation (blocking) of FLNA Binding (association) of associated with addiction, tolerance, narcan, mu opioid receptor, opiate and opioid
5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.32
The demonstration that both purified MOR and FLNA proteins bind to VAKGL suggests that the VAKGL pentapeptide can similarly prevent the MOR–FLNA interaction but by binding to either protein.
Negative_regulation (prevent) of FLNA Binding (interaction) of associated with mu opioid receptor
6) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.13

General Comments

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