INT221177

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Flna) plasma membrane (Flna) nucleus (Flna)
transcription factor binding (Flna) biological_process (Flna) cytoplasm (Flna)
Flna (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 175 100.00 Very High Very High Very High
mu opioid receptor 191 99.84 Very High Very High Very High
addiction 31 99.54 Very High Very High Very High
Morphine 111 99.30 Very High Very High Very High
tolerance 33 71.72 Quite High
Opioid 92 71.32 Quite High
analgesia 13 70.44 Quite High
antagonist 21 69.24 Quite High
Analgesic 8 51.76 Quite High
opiate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Opiate Addiction 4 5.00 Very Low Very Low Very Low
Drug Dependence 3 5.00 Very Low Very Low Very Low
Skin Cancer 3 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Bordatella Infection 1 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The dependence of [3H]NLX binding on FLNA expression in cell lines, the absence of MOR in these cell lines, and the displacement by naltrexone but not morphine clarified FLNA as a novel target for NLX and naltrexone.
Negative_regulation (absence) of Gene_expression (expression) of FLNA associated with addiction, mu opioid receptor, narcan and morphine
1) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.26
Acute morphine-induced G protein coupling switch blocked by 100 pM NLX/NTX or 10 ┬ÁM FLNA pentapeptide
Negative_regulation (blocked) of Gene_expression (pentapeptide) of FLNA associated with narcan and morphine
2) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 0.96

General Comments

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