INT221179

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.13
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Flna) plasma membrane (Flna) nucleus (Flna)
transcription factor binding (Flna) biological_process (Flna) cytoplasm (Flna)
Flna (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 216 99.80 Very High Very High Very High
Morphine 70 99.78 Very High Very High Very High
mu opioid receptor 188 99.18 Very High Very High Very High
addiction 28 96.88 Very High Very High Very High
tolerance 40 66.40 Quite High
Opioid 100 66.00 Quite High
analgesia 20 65.12 Quite High
antagonist 32 63.92 Quite High
Analgesic 10 46.44 Quite Low
opioid receptor 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 6 76.48 Quite High
Neuroblastoma 2 54.80 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Vibrio Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The exclusive presence of FLNA in the MOR/Go complexes led us to hypothesize that FLNA is the target through which ultra-low-dose NLX blocks the chronic morphine-induced switch from normal MOR–Gi/o coupling to Gs coupling.


Regulation (target) of FLNA associated with narcan, mu opioid receptor and morphine
1) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0.13 Pain Relevance 0.94
The dependence of [3H]NLX binding on FLNA expression in cell lines, the absence of MOR in these cell lines, and the displacement by naltrexone but not morphine clarified FLNA as a novel target for NLX and naltrexone.
Regulation (target) of FLNA associated with addiction, mu opioid receptor, narcan and morphine
2) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.10

General Comments

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