INT221180

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 2
Speculated 1
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 0.22
Pain Relevance 12.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (OPRM1, Flna) plasma membrane (OPRM1, Flna) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1) cytoplasm (Flna) cytosol (Flna)
Anatomy Link Frequency
upper 2
OPRM1 (Homo sapiens)
Flna (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 940 100.00 Very High Very High Very High
Morphine 350 100.00 Very High Very High Very High
narcan 1080 99.90 Very High Very High Very High
Opioid 500 99.68 Very High Very High Very High
tolerance 200 99.40 Very High Very High Very High
addiction 140 97.40 Very High Very High Very High
agonist 10 90.16 High High
gABA 10 83.44 Quite High
opiate 20 82.64 Quite High
Dopamine 10 82.20 Quite High
Disease Link Frequency Relevance Heat
Vibrio Infection 10 80.24 Quite High
Skin Cancer 30 42.16 Quite Low
Neuroblastoma 10 20.48 Low Low
Drug Dependence 10 14.72 Low Low
Pain 10 5.00 Very Low Very Low Very Low
Hyperalgesia 10 5.00 Very Low Very Low Very Low
Decapitation 10 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We deduced the precise binding site on FLNA by using overlapping peptides within the c-terminal, since c-terminal FLNA was shown to interact with MOR using a yeast-two hybrid [15].
MOR Binding (interact) of FLNA associated with mu opioid receptor
1) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 0.99
The final probing with a specific anti-FLNA antibody showed that FLNA associates with Go-coupled MOR and not with Gs-coupled MOR (Fig. 1 A,B).
Go-coupled MOR Neg (not) Binding (associates) of FLNA associated with mu opioid receptor
2) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.36
We identified a 300-kDa protein co-immunoprecipitating with MOR as FLNA and then demonstrated specific, high-affinity binding by NLX to FLNA.
MOR Binding (immunoprecipitating) of FLNA associated with narcan and mu opioid receptor
3) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 0.94
In agreement, our present slice culture data show that ultra-low-dose NLX, by binding to FLNA, prevents this morphine-induced desensitization measure, as well as the upstream MOR–Gs coupling that we previously showed to underlie tolerance and dependence in vivo [4].
MOR Binding (binding) of FLNA associated with addiction, tolerance, mu opioid receptor, narcan and morphine
4) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0.06 Pain Relevance 1.02
Alternatively, the fact that the attenuation of rewarding effects is diminished as the naltrexone dose increases could also suggest an upper limit of an effective ultra-low dose range for disrupting the FLNA–MOR interaction and consequent MOR–Gs signaling.
MOR Binding (interaction) of FLNA in upper associated with mu opioid receptor
5) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.56
Alternatively, the fact that the attenuation of rewarding effects is diminished as the naltrexone dose increases could also suggest an upper limit of an effective ultra-low dose range for disrupting the FLNA–MOR interaction and consequent MOR–Gs signaling.
MOR Binding (interaction) of FLNA in upper associated with mu opioid receptor
6) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.56
The detection of FLNA in immunoprecipitates containing Go-coupled MOR and not Gs-coupled MOR appears counterintuitive since NLX prevents MOR–Gs coupling via a tight binding to FLNA.
MOR Binding (binding) of FLNA associated with narcan and mu opioid receptor
7) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.39
This prior study by Onoprishvili et al., the first to show that FLNA interacts with the c-terminal of MOR, proposed a role for FLNA in receptor regulation and trafficking [15].
MOR Binding (interacts) of FLNA associated with mu opioid receptor
8) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0.08 Pain Relevance 1.10
The final probing with a specific anti-FLNA antibody showed that FLNA associates with Go-coupled MOR and not with Gs-coupled MOR (Fig. 1 A,B).
MOR Neg (not) Binding (associates) of FLNA associated with mu opioid receptor
9) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.37
MOR and FLNA might be forced into an altered conformation or interaction during opioid tolerance by proteins involved in MOR recycling and internalization such as ?
MOR Spec (might) Binding (interaction) of FLNA associated with tolerance, mu opioid receptor and opioid
10) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0.08 Pain Relevance 1.35

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