INT221182

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (OPRM1, Flna) plasma membrane (OPRM1, Flna) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1) cytoplasm (Flna) cytosol (Flna)
Anatomy Link Frequency
upper 2
OPRM1 (Homo sapiens)
Flna (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 94 100.00 Very High Very High Very High
addiction 14 92.40 High High
Opioid 50 91.56 High High
narcan 108 89.04 High High
gABA 1 84.04 Quite High
Dopamine 1 82.80 Quite High
antagonist 16 71.52 Quite High
analgesia 10 69.36 Quite High
Potency 1 68.08 Quite High
Oxycodone 3 67.28 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 1 14.72 Low Low
Skin Cancer 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 1 5.00 Very Low Very Low Very Low
Vibrio Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, the fact that the attenuation of rewarding effects is diminished as the naltrexone dose increases could also suggest an upper limit of an effective ultra-low dose range for disrupting the FLNA–MOR interaction and consequent MOR–Gs signaling.
Negative_regulation (disrupting) of MOR Binding (interaction) of FLNA in upper associated with mu opioid receptor
1) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.57

General Comments

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