INT221193

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.43
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
astrocyte 1
mct1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 38 88.04 High High
Neurotransmitter 2 59.64 Quite High
Glutamate 2 58.52 Quite High
potassium channel 76 5.00 Very Low Very Low Very Low
Bioavailability 6 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
action potential duration 4 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 116 80.88 Quite High
Diabetes Mellitus 2 74.72 Quite High
Starvation 2 72.48 Quite High
Stress 19 14.12 Low Low
Cancer 84 12.08 Low Low
Cv Unclassified Under Development 68 5.00 Very Low Very Low Very Low
Apoptosis 46 5.00 Very Low Very Low Very Low
Reperfusion Injury 30 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 16 5.00 Very Low Very Low Very Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is no overlap between SLC5A8 expression pattern and that of MCT1 (an astrocyte-specific MCT) and GFAP (a glial cell marker).
Gene_expression (expression) of MCT1 in astrocyte
1) Confidence 0.25 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0 Pain Relevance 0
There is a differential expression of MCT isoforms in neurons versus astrocytes, with MCT2 principally in neurons and MCT1 and MCT4 in astrocytes.
Gene_expression (expression) of MCT1 in neurons
2) Confidence 0.22 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0.15 Pain Relevance 0.06
This was demonstrated by the presence of monocarboxylate transporter 1 (MCT1) in the crude but not the purified mitochondria.
Gene_expression (presence) of MCT1
3) Confidence 0.18 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.29 Pain Relevance 0.04

General Comments

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