INT2212

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 1979
Last Reported 2010
Negated 4
Speculated 6
Reported most in Abstract
Documents 89
Total Number 96
Disease Relevance 18.36
Pain Relevance 63.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
neurons 5
brain 4
spinal cord 4
uterine 4
neuronal 4
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 1863 100.00 Very High Very High Very High
agonist 564 100.00 Very High Very High Very High
Glutamate 367 100.00 Very High Very High Very High
antagonist 217 100.00 Very High Very High Very High
GABAergic 174 100.00 Very High Very High Very High
Dopamine 149 100.00 Very High Very High Very High
adenocard 106 100.00 Very High Very High Very High
GABA receptor 77 100.00 Very High Very High Very High
Serotonin 56 100.00 Very High Very High Very High
nociceptor 29 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 1 100.00 Very High Very High Very High
Ganglion Cysts 60 99.68 Very High Very High Very High
Urological Neuroanatomy 65 99.60 Very High Very High Very High
Convulsion 241 99.56 Very High Very High Very High
Anxiety Disorder 384 99.48 Very High Very High Very High
Stress 103 99.24 Very High Very High Very High
Parkinson's Disease 19 99.10 Very High Very High Very High
Injury 95 98.84 Very High Very High Very High
Nervous System Injury 73 98.80 Very High Very High Very High
Epilepsy 169 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ketamine-induced rotation: interaction with GABA-transaminase inhibitors and picrotoxin.
GABA-transaminase Binding (interaction) of associated with gaba and ketamine
1) Confidence 0.48 Published 1979 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 575219 Disease Relevance 0 Pain Relevance 0.45
We conclude that Saffan produces antinociception in rats when given i.p. by an interaction with spinal GABA(A) receptors.
GABA Binding (interaction) of in spinal associated with antinociception and gaba
2) Confidence 0.48 Published 2000 Journal Pain Section Abstract Doc Link 11098097 Disease Relevance 0.09 Pain Relevance 0.95
This present study looks at the interaction of an intraperitoneal injection (i.p.) of the steroid anaesthetic combination Saffan (alphaxalone 9 mg/ml, alphadolone acetate 3 mg/ml) with GABA(A) receptors in the spinal cord.
GABA Binding (interaction) of in spinal cord associated with gaba and spinal cord
3) Confidence 0.48 Published 2000 Journal Pain Section Abstract Doc Link 11098097 Disease Relevance 0 Pain Relevance 0.76
These results suggest that P-GABA binds to GABA receptors causing enhanced cholinergic neurotransmission in the central nervous system.
P-GABA Binding (binds) of in central nervous system associated with gaba, gaba receptor and central nervous system
4) Confidence 0.43 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2982013 Disease Relevance 0 Pain Relevance 0.59
Both compounds increased the specific GABA receptor binding.
GABA Binding (binding) of associated with gaba receptor
5) Confidence 0.43 Published 1980 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 6258330 Disease Relevance 0.09 Pain Relevance 0.42
[Experimental changes of GABA receptor binding in the central nervous system (author's transl)].
GABA Binding (binding) of in central nervous system associated with gaba receptor and central nervous system
6) Confidence 0.43 Published 1980 Journal Wien. Klin. Wochenschr. Section Title Doc Link 6258330 Disease Relevance 0.09 Pain Relevance 0.57
These results suggest that gabapentin produces its effect on paired-pulse inhibition independent from the effect of baclofen and not through non-vesicular release of GABA interacting with the GABA(B) receptor system.
GABA Binding (interacting) of associated with gaba and gabapentin
7) Confidence 0.37 Published 1999 Journal Epilepsy Res. Section Abstract Doc Link 10094428 Disease Relevance 0 Pain Relevance 0.99
Little is known regarding either the role of this cotransmission in the generation of parkinsonian symptoms or of the nature of any functional interaction between GABA and enkephalin.
GABA Binding (interaction) of associated with parkinson's disease, gaba and enkephalin
8) Confidence 0.37 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 8307125 Disease Relevance 0.49 Pain Relevance 0.86
These results indicate that (a) GABA is released from rat pineals by a depolarizing stimulus of K+ through a mechanism which is partially Ca2+ dependent; (b) NE releases rat pineal GABA via interaction with alpha 1-adrenoceptors; (c) GABA inhibits melatonin production in vitro via interaction with GABA type A receptor sites; and (d) GABA's effect on NE-induced melatonin release does not correlate with the lack of effect on the NE-induced decrease in pineal 5-HT content.
GABA Binding (interaction) of associated with gaba
9) Confidence 0.37 Published 1989 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 2472890 Disease Relevance 0 Pain Relevance 0.86
Electrophysiological evidence for a non-opioid interaction between dynorphin and GABA in the substantia nigra of the rat.
GABA Binding (interaction) of in substantia nigra associated with gaba, dynorphin, substantia nigra, narcan and opioid
10) Confidence 0.36 Published 1987 Journal Neuroscience Section Title Doc Link 2893989 Disease Relevance 0 Pain Relevance 1.10
Total tritium efflux was measured as an index of GABA release.
GABA Binding (index) of associated with gaba
11) Confidence 0.36 Published 1988 Journal Neuroscience Section Abstract Doc Link 3217004 Disease Relevance 0 Pain Relevance 0.36
We conclude that thiocolchicoside may interact with a subpopulation of GABA(A) receptors having low-affinity binding sites for GABA.
GABA Binding (interact) of associated with gaba
12) Confidence 0.36 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11406196 Disease Relevance 0 Pain Relevance 0.41
The results indicate that partial sciatic nerve ligation decreases thermal and mechanical pain withdrawal latencies, and increases baclofen-stimulated [35S]GTPgammaS binding and GABA(B) receptor subunit gene expression in the rat lumbar spinal cord, suggesting that neuropathic pain may be due, in part, to a deficiency in GABAergic transmission.
GABA Binding (binding) of in spinal cord associated with pain, gaba, gabaergic, neuropathic pain, sciatic nerve, withdrawal and spinal cord
13) Confidence 0.34 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16293232 Disease Relevance 0.72 Pain Relevance 1.36
Pregabalin, an analog of gamma-aminobutyric acid (GABA) that does not interact with GABA receptors, is in development as an analgesic, an anticonvulsant, and an anxiolytic.
GABA Neg (not) Binding (interact) of associated with pregabalin, gaba, analgesic, gaba receptor, anxiety disorder and anticonvulsant
14) Confidence 0.33 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11714899 Disease Relevance 0.10 Pain Relevance 0.71
These results are discussed in terms of gamma-aminobutyric acid (GABA) since it is known that diazepam enhances binding of GABA to its receptor and hence potentiates inhibitory effects of GABA in the spinal cord.
GABA Binding (binding) of in spinal cord associated with gaba and spinal cord
15) Confidence 0.31 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3614765 Disease Relevance 0.17 Pain Relevance 0.36
Anticatatonic effect of clonidine: its interaction with dopaminergic, anticholinergic and GABA-ergic drugs.
GABA Binding (interaction) of associated with gaba and clonidine
16) Confidence 0.31 Published 1986 Journal Arch Int Pharmacodyn Ther Section Title Doc Link 3021074 Disease Relevance 0.24 Pain Relevance 0.98
Veratridine (Vtd: 100 microM in the dialysate) caused significant rises in both 3H and 14C content measured in the dialysates, the majority of which remained associated with the preload GABA and glutamate, respectively.
GABA Binding (associated) of associated with glutamate and gaba
17) Confidence 0.31 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1974602 Disease Relevance 0 Pain Relevance 0.60
In contrast, no difference in GABA binding between the injected and contralateral sides was observed in the same synaptosomal preparations that had been treated with GABA uptake inhibitors NNC-711, beta-alanine, or nipecotic acid.
GABA Binding (binding) of associated with gaba
18) Confidence 0.31 Published 2002 Journal Pain Section Abstract Doc Link 12127027 Disease Relevance 0 Pain Relevance 0.70
Synaptosomal preparations from the brainstem of rats that had received one or four facial carrageenan injections showed greater GABA binding on the side of the brainstem ipsilateral to the carrageenan injection than on the contralateral side when compared to saline injected controls.
GABA Binding (binding) of in brainstem associated with medulla and gaba
19) Confidence 0.31 Published 2002 Journal Pain Section Abstract Doc Link 12127027 Disease Relevance 0 Pain Relevance 0.55
The difference between GABA binding in the absence of the GABA uptake inhibitor and GABA binding in a portion from the same synaptosomal preparation which had been incubated with the GABA uptake inhibitor was obtained to represent [(3)H] GABA binding to GABA transporters/transporter mediated [(3)H] GABA uptake.
GABA Binding (binding) of associated with gaba
20) Confidence 0.31 Published 2002 Journal Pain Section Abstract Doc Link 12127027 Disease Relevance 0.05 Pain Relevance 0.84

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox