INT221201

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.02
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cartilage 1
articular cartilage 1
Ppi-rs (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 45 99.54 Very High Very High Very High
withdrawal 2 94.92 High High
potassium channel 76 93.60 High High
Eae 12 93.24 High High
cytokine 12 84.40 Quite High
nMDA receptor antagonist 1 81.64 Quite High
depression 9 64.48 Quite High
monoamine 13 54.00 Quite High
Dopamine 11 46.72 Quite Low
Hippocampus 7 26.08 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 45 99.54 Very High Very High Very High
Pressure And Volume Under Development 4 99.44 Very High Very High Very High
Aging 39 99.40 Very High Very High Very High
Targeted Disruption 121 99.28 Very High Very High Very High
Chondrocalcinosis 9 99.20 Very High Very High Very High
Congenital Anomalies 18 99.12 Very High Very High Very High
Calcification 138 97.52 Very High Very High Very High
Cognitive Disorder 12 90.32 High High
Akathisia 1 74.20 Quite High
Osteoporosis 12 73.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NPP1 and PPi deficiency states are linked to accelerated chondrogenesis
PPi Binding (linked) of
1) Confidence 0.04 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.39 Pain Relevance 0.04
This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.
PPi Binding (association) of in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis
2) Confidence 0.04 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.59 Pain Relevance 0.28
Extracellular PPi rises markedly in articular cartilage in direct association with aging and OA, and resultant matrix supersaturation with PPi and cartilage matrix abnormalities that alter the solubility product of PPi and Ca2+ promote calcification [42].
PPi Binding (supersaturation) of in cartilage associated with calcification, aging, congenital anomalies and osteoarthritis
3) Confidence 0.04 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.60 Pain Relevance 0.13
In contrast, atypical antipsychotics (clozapine and risperidone) ameliorated the impairments of social interaction and PPI.
PPI Binding (interaction) of
4) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 1.34 Pain Relevance 0.22
Since PPi was known to bind to the ANT [199–201] and adenine nucleotide depletion had been reported to increase mitochondrial K+ uptake [202,203], we proposed that the ANT could act as a potassium channel when ATP was displaced by PPi [186].
PPi Binding (bind) of associated with potassium channel
5) Confidence 0.01 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.10 Pain Relevance 0.11

General Comments

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