INT221206

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.13
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) signal transduction (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1)
plasma membrane (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Pdpk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 154 95.44 Very High Very High Very High
bradykinin 6 93.24 High High
adenocard 8 92.64 High High
agonist 6 70.84 Quite High
Morphine 154 67.12 Quite High
tolerance 56 61.88 Quite High
opioid receptor 168 58.32 Quite High
Delta opioid receptors 2 57.48 Quite High
antagonist 18 56.44 Quite High
analgesia 8 55.36 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 232 64.88 Quite High
Apoptosis 34 17.20 Low Low
Cv Unclassified Under Development 136 5.00 Very Low Very Low Very Low
Reperfusion Injury 60 5.00 Very Low Very Low Very Low
Stress 38 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 36 5.00 Very Low Very Low Very Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Nociception 14 5.00 Very Low Very Low Very Low
Injury 14 5.00 Very Low Very Low Very Low
Death 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Akt activation is dependent on phosphorylation of two sites: PDK1 phosphorylation of Thr308 in the kinase activation loop and PDK2 phosphorylation of Ser473 at the C-terminus (6).
Phosphorylation (phosphorylation) of PDK1
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.53
Akt activation is dependent on phosphorylation of two sites: PDK1 phosphorylation of Thr308 in the kinase activation loop and PDK2 phosphorylation of Ser473 at the C-terminus (6).
Phosphorylation (phosphorylation) of PDK1
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.53
The resulting phosphatidylinositol 3,4-bisphosphate then activates phosphoinositide-dependent kinase 1 (PDK1) that in turn phosphorylates and activates Akt.
Phosphorylation (phosphorylates) of PDK1
3) Confidence 0.37 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.06 Pain Relevance 0.09
The resulting phosphatidylinositol 3,4-bisphosphate then activates phosphoinositide-dependent kinase 1 (PDK1) that in turn phosphorylates and activates Akt.
Phosphorylation (phosphorylates) of phosphoinositide-dependent kinase 1
4) Confidence 0.37 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.06 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox