INT221207

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Context Info
Confidence 0.74
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.76
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn2) endoplasmic reticulum (Ptpn2) nucleus (Ptpn2)
cytoplasm (Ptpn2)
Anatomy Link Frequency
blood 1
neurons 1
brain 1
Ptpn2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 4 99.48 Very High Very High Very High
monoamine 5 97.12 Very High Very High Very High
anesthesia 4 95.96 Very High Very High Very High
Dopamine 54 93.60 High High
Inflammation 43 92.92 High High
Substantia nigra 35 82.24 Quite High
Inflammatory marker 1 59.48 Quite High
cINOD 27 27.68 Quite Low
potassium channel 76 5.00 Very Low Very Low Very Low
Kinase C 38 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 451 100.00 Very High Very High Very High
INFLAMMATION 53 99.48 Very High Very High Very High
Disease 197 96.84 Very High Very High Very High
Cv Unclassified Under Development 69 96.04 Very High Very High Very High
Death 27 92.80 High High
Tremor 4 86.04 High High
Movement Disorders 6 85.44 High High
Aging 24 79.20 Quite High
Neurodegenerative Disease 17 79.12 Quite High
Drug Induced Neurotoxicity 26 77.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once inside the brain, MPTP is metabolized into the toxic cation 1-methyl-4-phenylpyridinium (MPP+) by the enzyme monoamine oxidase B (MAO-B) in glial cells.
Localization (metabolized) of MPTP in brain associated with parkinson's disease and monoamine
1) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 1.60 Pain Relevance 0.17
For the continuous infusion of MPTP, an osmotic minipump (ALZET model 2004, USA) was transplanted subcutaneously, releasing either saline solution or MPTP solution at 45 mg/kg daily.
Localization (releasing) of MPTP associated with parkinson's disease
2) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 1.00 Pain Relevance 0.21
HCT1026-induced neuroprotection was associated with a marked down-regulation of activated microglial cell number and a signiof ficant decrease of MPTP-induced pro-inflammatory mediators, including iNOS, Mac-1 and PHOX expression, as well reduced 3-NT formationin SNpc DAergic neurons, suggesting that a switch in microglia pro-inflammatory phenotype might contribute to nigrostriatal neuroprotection.
Localization (decrease) of MPTP in neurons associated with parkinson's disease, inflammatory mediators and inflammation
3) Confidence 0.58 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.99 Pain Relevance 0.16
However, these studies relied on cytochrome c release as a measure of MPTP opening, but it is known that this can occur independently of the MPTP as a result of Bax translocation to mitochondria during ischaemia [72].
Localization (release) of MPTP associated with parkinson's disease and cv unclassified under development
4) Confidence 0.36 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 1.34 Pain Relevance 0
MPTP cross the blood brain barrier and is converted to 1-methyl 4 phenylpyridinium (MPP+) within glial cells and then released to the extracellular space.
Localization (released) of MPTP in blood associated with parkinson's disease
5) Confidence 0.19 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.83 Pain Relevance 0.05

General Comments

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