INT221210

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 8.30
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn2) endoplasmic reticulum (Ptpn2) nucleus (Ptpn2)
cytoplasm (Ptpn2)
Anatomy Link Frequency
neuronal 2
neuron 2
hearts 2
dopaminergic neurons 2
Ptpn2 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 20 99.92 Very High Very High Very High
COX-2 inhibitor 10 99.22 Very High Very High Very High
Substantia nigra 96 98.20 Very High Very High Very High
monoamine 5 91.00 High High
anesthesia 7 85.60 High High
Dopamine 64 80.08 Quite High
cytokine 17 78.64 Quite High
imagery 10 64.96 Quite High
potassium channel 228 58.72 Quite High
Neurotransmitter 1 58.56 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 744 100.00 Very High Very High Very High
Disease 237 99.84 Very High Very High Very High
Reperfusion Injury 90 99.12 Very High Very High Very High
Cv Unclassified Under Development 207 98.94 Very High Very High Very High
Toxicity 21 98.20 Very High Very High Very High
Apoptosis 54 96.00 Very High Very High Very High
Death 31 95.24 Very High Very High Very High
Drug Induced Neurotoxicity 33 92.20 High High
Injury 35 89.68 High High
Stress 118 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute injection and continuous infusion of MPTP
Negative_regulation (infusion) of Gene_expression (injection) of MPTP associated with parkinson's disease
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.95 Pain Relevance 0.14
Although some microglia in the SN were activated in 24 h, we can conclude that DHE signals which we observed in 24 h after MPTP injection mostly reflected neuronal O2•?
Negative_regulation (reflected) of Gene_expression (injection) of MPTP in neuronal associated with parkinson's disease and substantia nigra
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.40 Pain Relevance 0.19
The result showed that drinking H2/Mg water reduced the loss of dopaminergic neurons even after MPTP injection (Figure 3B, 3C; 16% & 17% recovery in drinking protocol shown as A&B, respectively).
Negative_regulation (reduced) of Gene_expression (injection) of MPTP in dopaminergic neurons associated with parkinson's disease
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.88 Pain Relevance 0
The striatal levels of MPP+ were then measured 90 min after MPTP injection in mice fed with the different diets and exposed to MPTP.
Negative_regulation (measured) of Gene_expression (injection) of MPTP associated with parkinson's disease
4) Confidence 0.29 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.40 Pain Relevance 0.05
Protection by preconditioning involves inhibition of MPTP opening
Negative_regulation (inhibition) of Gene_expression (opening) of MPTP associated with parkinson's disease
5) Confidence 0.22 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 1.32 Pain Relevance 0
Inhibition of MPTP opening protects hearts from reperfusion injury
Negative_regulation (Inhibition) of Gene_expression (opening) of MPTP in hearts associated with parkinson's disease and reperfusion injury
6) Confidence 0.22 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 1.31 Pain Relevance 0
As such they provide strong evidence in favour of IP exerting its primary effect on the reduction of ROS levels during ischaemia and reperfusion with the secondary consequence that MPTP opening is diminished.
Negative_regulation (diminished) of Gene_expression (opening) of MPTP associated with parkinson's disease and cv unclassified under development
7) Confidence 0.22 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 1.04 Pain Relevance 0.08
The selective COX-2 inhibitor rofecoxib blocked ventral midbrain PG production in MPTP injected mice and attenuated neuron and fiber loss, demonstrating the crucial enzymatic function of COX-2 to its neurotoxic effects on dopaminergic neurons.
Negative_regulation (attenuated) of Gene_expression (production) of MPTP in neuron associated with parkinson's disease, midbrain and cox-2 inhibitor
8) Confidence 0.08 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866462 Disease Relevance 0.52 Pain Relevance 0.21
The AAV2 model is very different from MPTP neurotoxin models of PD, but role of NF-?
Negative_regulation (different) of Gene_expression (models) of MPTP associated with parkinson's disease and disease
9) Confidence 0.08 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.49 Pain Relevance 0.17

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