INT221213

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 2.79
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa9) protein folding (Hspa9) mitochondrion (Hspa9)
enzyme binding (Hspa9) response to stress (Hspa9) cytoplasm (Hspa9)
Anatomy Link Frequency
lymphocyte 1
Hspa9 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 40 100.00 Very High Very High Very High
Pain 44 98.32 Very High Very High Very High
medulla 24 97.88 Very High Very High Very High
Inflammation 121 97.84 Very High Very High Very High
cytokine 140 93.28 High High
Spinal cord 106 92.36 High High
potassium channel 76 73.68 Quite High
anesthesia 11 73.36 Quite High
Osteoarthritis 60 62.04 Quite High
substance P 9 12.12 Low Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 116 99.98 Very High Very High Very High
Disease 58 98.68 Very High Very High Very High
INFLAMMATION 117 97.84 Very High Very High Very High
Myositis 42 96.52 Very High Very High Very High
Nociception 10 95.08 Very High Very High Very High
Disease Progression 39 93.36 High High
Chemotherapy-induced Neutropenia 12 92.20 High High
Pain 48 90.20 High High
Death 26 81.96 Quite High
Shock 1 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, data concerning Grp94, calreticulin and Grp75 are presently lacking.
Negative_regulation (lacking) of Grp75
1) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.54 Pain Relevance 0
Although involved QFM CSA decreased by approximately 10% postoperatively in both groups, it was only significant in the NMES group (p < 0.05).
Negative_regulation (decreased) of CSA
2) Confidence 0.27 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896350 Disease Relevance 0 Pain Relevance 0
QFM CSA decreased by 4% in the NMES group compared to a reduction of 12% in the control group (P > 0.05) at 12 weeks postoperatively compared to baseline.
Negative_regulation (decreased) of CSA
3) Confidence 0.27 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2896350 Disease Relevance 0.12 Pain Relevance 0.06
When QFM CSA at 12 weeks post-TKA was compared to baseline levels, it had decreased by 3.7% in the NMES group while a reduction of 12.1% (p > 0.05) was found in the control group.
Negative_regulation (decreased) of CSA
4) Confidence 0.27 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896350 Disease Relevance 0 Pain Relevance 0
We suggest that the inhibitory mechanism of RAE and CsA
Negative_regulation (mechanism) of CsA
5) Confidence 0.21 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.21 Pain Relevance 0.05
This study aims to analyze the interference of MTX and CsA, each one daily administered alone or combined during 21 days, on the activity levels of S DPPIV and POP, and MDPPIV in two distinct status of ex
Spec (analyze) Negative_regulation (interference) of CsA associated with methotrexate
6) Confidence 0.21 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 1.00 Pain Relevance 0.66
All animals, excluding the hTgn and C57BL/6 groups, were immunosuppressed with CsA (10 mg/kg ip per day) during the post-transplantation period.


Negative_regulation (immunosuppressed) of CsA
7) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.40 Pain Relevance 0.07
mRNA expression was detected in Media (p<0.05), CsA (p<0.001), MNC hUCB 50×106 (p<0.05) vs. control hTgn or C57BL/6 mice.
Negative_regulation (detected) of CsA
8) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.27
The lymphocyte percentage was significantly decreased in Media (p<0.001) and CsA (p<0.001) groups compared to those in hTgn.
Negative_regulation (decreased) of CsA in lymphocyte
9) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.09 Pain Relevance 0.03
Hausenloy and colleagues have reported that when the MPTP inhibitors CsA or SfA are present during IP or preconditioning induced by uncoupler and diazoxide, cardioprotection is abolished [121].
Negative_regulation (inhibitors) of CsA associated with parkinson's disease
10) Confidence 0.05 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.42 Pain Relevance 0.04

General Comments

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