INT221216

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.65
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gja3) plasma membrane (Gja3)
Anatomy Link Frequency
hearts 3
endothelial cells 1
CAR 1
cardiomyocytes 1
Gja3 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 25 99.68 Very High Very High Very High
Kinase C 304 99.06 Very High Very High Very High
addiction 11 90.84 High High
potassium channel 610 83.80 Quite High
imagery 11 67.56 Quite High
Action potential 18 65.20 Quite High
fibrosis 3 43.48 Quite Low
anesthesia 19 22.48 Low Low
isoflurane 4 14.76 Low Low
action potential duration 52 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 546 99.68 Very High Very High Very High
Targeted Disruption 294 99.32 Very High Very High Very High
Parkinson's Disease 928 95.84 Very High Very High Very High
Reperfusion Injury 240 92.08 High High
Shock 8 90.36 High High
Injury 48 86.36 High High
Myelodysplastic Syndromes 3 68.40 Quite High
Arrhythmia Under Development 57 58.96 Quite High
Disease 21 46.04 Quite Low
Embryonic Lethality 6 44.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that short-term pacing, if imposed on murine hearts with decreased Cx43 abundance, could serve as a model for evaluating the electrophysiological effects of GJR.
Localization (abundance) of Cx43 in hearts
1) Confidence 0.65 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Abstract Doc Link PMC2614590 Disease Relevance 0.09 Pain Relevance 0.03
On a molecular level, the functional interaction of gap and tight junction is supported by coprecipitation and colocalization of Cx40 and Cx43 with tight junction molecules occludin, claudin-5, and ZO-1 in endothelial cells (25).
Localization (colocalization) of Cx43 in endothelial cells
2) Confidence 0.40 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.74 Pain Relevance 0.05
The primary antibodies used were the following: rat anti-HCN4 (Abcam) and anti-CAR (rabbit polyclonal, raised against the Fc fusion protein containing the CA extracellular domain), anti-CAR (rabbit polyclonal; Santa Cruz Biotechnology, Inc.), anti–N-cadherin (mouse monoclonal; Invitrogen), anti-Cx43 (mouse monoclonal; Invitrogen), and anti–?
Localization (anti) of Cx43 in CAR
3) Confidence 0.37 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.07 Pain Relevance 0.03
Although the expression and localization of the adherens junction protein N-cadherin was unaffected (Fig. 7 B), the localization of the gap junction protein Connexin 43 (Cx43) was altered in KO cardiomyocytes 8 wk after induction (Fig. 7 C).
Localization (localization) of Cx43 in cardiomyocytes associated with targeted disruption
4) Confidence 0.35 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.39 Pain Relevance 0
Furthermore, sub-fractionation of mitochondrial compartments led the authors to conclude that Cx43 is translocated to the inner mitochondrial membrane, although some Cx43 may remain associated with the outer membrane [257].
Localization (translocated) of Cx43
5) Confidence 0.21 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.24 Pain Relevance 0.05
Thus the balance of evidence suggests that Cx43 translocation to mitochondria is not essential for preconditioning [256].


Localization (translocation) of Cx43
6) Confidence 0.21 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.34 Pain Relevance 0.04
Thus the relevance of Cx43 translocation to the mitochondria remains uncertain, although the loss of preconditioning in Cx43-deficient hearts from mice argues strongly for some pool of Cx43 playing a critical role [247,261].
Localization (translocation) of Cx43 in hearts
7) Confidence 0.21 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0 Pain Relevance 0.03
Recent work has suggested that this may be through a translocation of Cx43 to the mitochondria following preconditioning [255–257].
Localization (translocation) of Cx43
8) Confidence 0.21 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.54 Pain Relevance 0.14
Furthermore the cardioprotective effects of both diazoxide and isoprenaline were not accompanied by translocation of Cx43 to the mitochondria [257].
Localization (translocation) of Cx43
9) Confidence 0.21 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.33 Pain Relevance 0.04
Studies in both pig and rat hearts demonstrated that the dephosphorylation of Cx43 and electrical uncoupling during ischaemia were prevented by IP in a PKC-dependent manner and that IP increased the co-localization of several protein kinases with Cx43 during ischemia [262,263].
Localization (localization) of Cx43 in hearts associated with kinase c, ischemia and cv unclassified under development
10) Confidence 0.20 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.62 Pain Relevance 0.21
Furthermore, sub-fractionation of mitochondrial compartments led the authors to conclude that Cx43 is translocated to the inner mitochondrial membrane, although some Cx43 may remain associated with the outer membrane [257].
Localization (translocated) of Cx43
11) Confidence 0.18 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.24 Pain Relevance 0.05
Although we have been able to detect Cx43 in purified mitochondria, and in preliminary experiments show that this was increased following preconditioning, we have expressed reservations about the likelihood of Cx43 translocation to the inner mitochondrial membrane [256].
Localization (translocation) of Cx43
12) Confidence 0.18 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.06 Pain Relevance 0

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