INT221242

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.39
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ros1, Prkca) kinase activity (Ros1, Prkca) cell differentiation (Ros1)
mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
Anatomy Link Frequency
heart 2
Ros1 (Mus musculus)
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 114 100.00 Very High Very High Very High
Opioid 3 86.12 High High
noradrenaline 3 85.64 High High
bradykinin 9 85.04 High High
adenocard 12 84.56 Quite High
potassium channel 228 80.44 Quite High
action potential duration 12 5.00 Very Low Very Low Very Low
ischemia 9 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 348 98.32 Very High Very High Very High
Cv Unclassified Under Development 204 69.88 Quite High
Reperfusion Injury 90 47.24 Quite Low
Targeted Disruption 24 42.16 Quite Low
Stress 57 5.00 Very Low Very Low Very Low
Apoptosis 48 5.00 Very Low Very Low Very Low
Injury 18 5.00 Very Low Very Low Very Low
Death 15 5.00 Very Low Very Low Very Low
Thrombosis Related Under Development 12 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus ROS are known to activate PKC in the isolated heart [118–120] and IP can be prevented if free radical scavengers are present during the preconditioning phase [100,101,118,121] Oxidation of critical cysteine residues on PKC isoforms is known to cause their activation [35,122] and thus provides a mechanism by which ROS could activate PKC.


ROS Positive_regulation (activate) of PKC in heart associated with kinase c
1) Confidence 0.02 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.06 Pain Relevance 0.56
Thus ROS are known to activate PKC in the isolated heart [118–120] and IP can be prevented if free radical scavengers are present during the preconditioning phase [100,101,118,121] Oxidation of critical cysteine residues on PKC isoforms is known to cause their activation [35,122] and thus provides a mechanism by which ROS could activate PKC.


ROS Positive_regulation (activate) of PKC in heart associated with kinase c
2) Confidence 0.01 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.18 Pain Relevance 0.62
In a subsequent paper they proposed that activation of the mitoKATP channel increased ROS formation and that this ROS activated a second pool of PKC?
ROS Positive_regulation (activated) of PKC associated with kinase c
3) Confidence 0.01 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.15 Pain Relevance 0.27

General Comments

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