INT221257

Context Info Confidence 0.07 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.19 Pain Relevance 0.86

cytosol (Pde5a, PRKG1) signal transduction (Pde5a, PRKG1) plasma membrane (PRKG1) cytoplasm (PRKG1)

Anatomy Link Frequency synapses 1 Pde5a (Mus musculus) PRKG1 (Homo sapiens)

Pain Link Frequency Relevance Heat potassium channel 76 97.88 nMDA receptor 29 96.76 Kinase C 41 93.76 Glutamate 9 87.28 long-term potentiation 66 72.32 depression 19 72.04 Neuronal excitability 4 67.76 Opioid 1 46.20 noradrenaline 1 45.72 bradykinin 4 45.12

Disease Link Frequency Relevance Heat Depression 19 72.04 Parkinson's Disease 117 62.16 Cognitive Disorder 95 50.00 Cv Unclassified Under Development 70 29.96 Reperfusion Injury 30 7.32 Targeted Disruption 26 5.00 Stress 22 5.00 Apoptosis 16 5.00 Anxiety Disorder 12 5.00 Injury 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There are indications that, postsynaptically, cGMP has similar effects as cAMP, but via the activation of PKG.

cGMP Positive_regulation (activation) of PKG

1) Confidence 0.07 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.30

According to the current model, NO is produced either in parallel fibres themselves (Shibuki & Kimura, 1997) or via NMDA receptor activity in interneurones simultaneously receiving parallel fibre excitation (Shin & Linden, 2005) and acts postsynaptically at parallel fibre synapses to raise cGMP and thence activate PKG.

cGMP Positive_regulation (activate) of PKG in synapses associated with nmda receptor

2) Confidence 0.02 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.13 Pain Relevance 0.19

They propose that cGMP activates PKG localized at the cytosolic surface of the mitochondrial outer membrane and that this phosphorylates some target protein which in turn can somehow activate PKC?

cGMP Positive_regulation (activates) of PKG associated with kinase c

3) Confidence 0.00 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.06 Pain Relevance 0.37

General Comments

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