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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.19
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a, PRKG1) signal transduction (Pde5a, PRKG1) plasma membrane (PRKG1)
cytoplasm (PRKG1)
Anatomy Link Frequency
synapses 1
Pde5a (Mus musculus)
PRKG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 76 97.88 Very High Very High Very High
nMDA receptor 29 96.76 Very High Very High Very High
Kinase C 41 93.76 High High
Glutamate 9 87.28 High High
long-term potentiation 66 72.32 Quite High
depression 19 72.04 Quite High
Neuronal excitability 4 67.76 Quite High
Opioid 1 46.20 Quite Low
noradrenaline 1 45.72 Quite Low
bradykinin 4 45.12 Quite Low
Disease Link Frequency Relevance Heat
Depression 19 72.04 Quite High
Parkinson's Disease 117 62.16 Quite High
Cognitive Disorder 95 50.00 Quite Low
Cv Unclassified Under Development 70 29.96 Quite Low
Reperfusion Injury 30 7.32 Low Low
Targeted Disruption 26 5.00 Very Low Very Low Very Low
Stress 22 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Injury 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are indications that, postsynaptically, cGMP has similar effects as cAMP, but via the activation of PKG.
cGMP Positive_regulation (activation) of PKG
1) Confidence 0.07 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.30
According to the current model, NO is produced either in parallel fibres themselves (Shibuki & Kimura, 1997) or via NMDA receptor activity in interneurones simultaneously receiving parallel fibre excitation (Shin & Linden, 2005) and acts postsynaptically at parallel fibre synapses to raise cGMP and thence activate PKG.
cGMP Positive_regulation (activate) of PKG in synapses associated with nmda receptor
2) Confidence 0.02 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.13 Pain Relevance 0.19
They propose that cGMP activates PKG localized at the cytosolic surface of the mitochondrial outer membrane and that this phosphorylates some target protein which in turn can somehow activate PKC?
cGMP Positive_regulation (activates) of PKG associated with kinase c
3) Confidence 0.00 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.06 Pain Relevance 0.37

General Comments

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