INT221259

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a, PRKG1) signal transduction (Pde5a, PRKG1) plasma membrane (PRKG1)
cytoplasm (PRKG1)
Pde5a (Mus musculus)
PRKG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 76 97.88 Very High Very High Very High
Kinase C 38 94.16 High High
Opioid 1 46.20 Quite Low
noradrenaline 1 45.72 Quite Low
bradykinin 3 45.12 Quite Low
adenocard 4 44.64 Quite Low
action potential duration 4 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 116 62.96 Quite High
Cv Unclassified Under Development 68 29.96 Quite Low
Reperfusion Injury 30 7.32 Low Low
Stress 19 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Thrombosis Related Under Development 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They propose that cGMP activates PKG localized at the cytosolic surface of the mitochondrial outer membrane and that this phosphorylates some target protein which in turn can somehow activate PKC?
cGMP Positive_regulation (activates) of Localization (localized) of PKG associated with kinase c
1) Confidence 0.00 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.06 Pain Relevance 0.37

General Comments

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