INT221268

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.83
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (BRCA1) chromosome segregation (BRCA1) intracellular (BRCA1)
enzyme binding (BRCA1) DNA binding (BRCA1) protein complex (BRCA1)
Anatomy Link Frequency
lymph node 1
external 1
BRCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 14 70.60 Quite High
Pain 4 65.76 Quite High
cannabis 2 59.36 Quite High
Morphine 2 52.40 Quite High
Inflammation 18 50.00 Quite Low
cocaine 4 48.24 Quite Low
alcohol 12 40.08 Quite Low
methadone 10 9.12 Low Low
imagery 18 5.00 Very Low Very Low Very Low
abdominal pain 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immune Reconstitution Inflammatory Syndrome 130 100.00 Very High Very High Very High
Disease 100 100.00 Very High Very High Very High
Breast Cancer 192 99.96 Very High Very High Very High
Endometriosis (extended) 6 97.64 Very High Very High Very High
Genomic Instability 1 97.40 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 31 96.16 Very High Very High Very High
Death 28 95.76 Very High Very High Very High
Chromosomal Instability 1 95.20 Very High Very High Very High
Cancer 141 94.08 High High
Alcohol Addiction 3 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increasing knowledge of BRCA1 and BRCA2 acts as an exemplar resulting in improved patient care.
Localization (knowledge) of BRCA1
1) Confidence 0.63 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 0.68 Pain Relevance 0
Early onset drug use commenced for most of those interviewed during adolescence or early adulthood as a consequence of recreational use, experimentation, escape or part of the ‘hippie era’, or was triggered by child abuse and/or a parent dying, as this typical quote indicates:

‘Late onset’ problematic use of illicit drugs began later in the life course for some due to stressful life events such as divorce or death, or because of close personal relationships with a ‘drug user’, evidenced by this man talking about his partner:

Localization (use) of Late onset associated with death
2) Confidence 0.54 Published 2010 Journal Journal of Advanced Nursing Section Body Doc Link PMC2984546 Disease Relevance 0.18 Pain Relevance 0.08
Early onset drug use commenced for most of those interviewed during adolescence or early adulthood as a consequence of recreational use, experimentation, escape or part of the ‘hippie era’, or was triggered by child abuse and/or a parent dying, as this typical quote indicates:

‘Late onset’ problematic use of illicit drugs began later in the life course for some due to stressful life events such as divorce or death, or because of close personal relationships with a ‘drug user’, evidenced by this man talking about his partner:

Localization (use) of Early onset associated with death
3) Confidence 0.54 Published 2010 Journal Journal of Advanced Nursing Section Body Doc Link PMC2984546 Disease Relevance 0.17 Pain Relevance 0
Nonetheless, the observations of the current study – that adequate immunologic responses to HAART and peripheral lymph node location of MAC IRIS may be associated with favorable outcomes, may be useful for physicians managing patients with AIDS who develop MAC IRIS.


Localization (location) of IRIS in lymph node associated with immune reconstitution inflammatory syndrome and acquired immune deficiency syndrome or hiv infection
4) Confidence 0.48 Published 2007 Journal J Transl Med Section Body Doc Link PMC2213635 Disease Relevance 0.68 Pain Relevance 0.04
There has been insufficient information published in the literature regarding the characteristics of patients who do not respond to initial antimycobacterial therapy and who develop persistent MAC IRIS disease.
Localization (disease) of IRIS associated with immune reconstitution inflammatory syndrome and disease
5) Confidence 0.48 Published 2007 Journal J Transl Med Section Body Doc Link PMC2213635 Disease Relevance 1.00 Pain Relevance 0
If somatic mutations or epigenetic silencing leads to the absence of either BRCA1 or BRCA2, alternative DNA repair pathways such as nonhomologous end joining are employed; this subsequently results in chromosomal instability and cell death [54].
Neg (absence) Localization (absence) of BRCA1 associated with chromosomal instability and death
6) Confidence 0.24 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2814233 Disease Relevance 0.80 Pain Relevance 0.07
The risk factors for breast carcinoma are age, early menarche, later menopause, nulliparity, later first pregnancy, medical history, family history with first-degree relatives with breast cancer, presence of the mutation BRCA1 and BRCA2, previous thoracic external radiotherapy, high breast density in mammography, use of hormones (high doses of estrogens and progesterone), alcoholism, and the Caucasian race [5,13,16].
Localization (presence) of BRCA1 in external associated with alcohol addiction, endometriosis (extended) and breast cancer
7) Confidence 0.09 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC3022674 Disease Relevance 1.32 Pain Relevance 0

General Comments

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