INT221269

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 23
Disease Relevance 31.77
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (BRCA1) chromosome segregation (BRCA1) intracellular (BRCA1)
enzyme binding (BRCA1) DNA binding (BRCA1) protein complex (BRCA1)
Anatomy Link Frequency
body 1
BRCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 392 100.00 Very High Very High Very High
abdominal pain 19 99.98 Very High Very High Very High
Inflammation 451 99.80 Very High Very High Very High
Central nervous system 181 99.28 Very High Very High Very High
corticosteroid 27 98.24 Very High Very High Very High
Neuritis 20 86.08 High High
headache 20 75.44 Quite High
cva 10 73.68 Quite High
Inflammatory stimuli 2 59.32 Quite High
Inflammatory marker 10 53.60 Quite High
Disease Link Frequency Relevance Heat
Immune Reconstitution Inflammatory Syndrome 2497 100.00 Very High Very High Very High
Cancer 591 100.00 Very High Very High Very High
Male Breast Neoplasms 4 100.00 Very High Very High Very High
Cryptococcal Meningitis 1020 99.98 Very High Very High Very High
Abdominal Pain 19 99.98 Very High Very High Very High
INFLAMMATION 461 99.80 Very High Very High Very High
Death 178 99.80 Very High Very High Very High
Breast Cancer 483 99.68 Very High Very High Very High
Carcinoma 27 99.60 Very High Very High Very High
Mycobacterial Infection 121 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also need to find other proteins that interact with BRCA1 and BRCA2 and elucidate the post-translational modifications that occur as a result of these interactions.
BRCA1 Binding (interact) of
1) Confidence 0.40 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 0.75 Pain Relevance 0
Whether our findings in BRCA1 carriers can be generalized to serous ovarian cancers in general, including sporadic or non-BRCA1 familial cases, is still an important question.
BRCA1 Binding (findings) of associated with ovarian cancer
2) Confidence 0.36 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2711307 Disease Relevance 0.72 Pain Relevance 0
For example, the second susceptibility locus for breast cancer, BRCA2, was mapped by Wooster et al. [37] based on high-risk families for whom BRCA1 linkage was excluded.
BRCA1 Binding (linkage) of associated with breast cancer
3) Confidence 0.35 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2488325 Disease Relevance 0.76 Pain Relevance 0
Sporadic breast cancer is not usually associated with other cancers such as ovarian or male breast cancer and unlike BRCA1-positive carcinomas, which exhibit specific histological characteristics, sporadic breast cancer cases comprise a vast array of phenotypes.
BRCA1 Neg (not) Binding (associated) of associated with male breast neoplasms, cancer, breast cancer and carcinoma
4) Confidence 0.29 Published 2010 Journal Current Genomics Section Body Doc Link PMC2878980 Disease Relevance 1.38 Pain Relevance 0
Further analysis has shown that allelic variation at FGFR2, TNRC9, 8q24, 2q35, and 5p12 is associated with physiological characteristics of breast tumors, such as ER status [62, 64, 65], and specific FGFR2, MAP3K1, and TNRC9 variants may interact with BRCA1 and BRCA2 mutations to increase breast cancer risk [66].
BRCA1 Binding (interact) of associated with breast cancer
5) Confidence 0.28 Published 2010 Journal Current Genomics Section Body Doc Link PMC2878980 Disease Relevance 0.70 Pain Relevance 0
In patients with initial recovery after antituberculosis treatment and then a subsequent deterioration after starting antiretroviral therapy, the presence of a resistant strain of TB should be excluded before establishing a diagnosis of IRIS.
IRIS Binding (diagnosis) of associated with mycobacterial infection, immune reconstitution inflammatory syndrome and sprains and strains
6) Confidence 0.25 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2988055 Disease Relevance 2.55 Pain Relevance 0
Because of significant abdominal pain associated with MAC IRIS involving the gastrointestinal tract, oral corticosteroids were initiated.
IRIS Binding (associated) of associated with corticosteroid, abdominal pain and immune reconstitution inflammatory syndrome
7) Confidence 0.24 Published 2007 Journal J Transl Med Section Body Doc Link PMC2213635 Disease Relevance 1.26 Pain Relevance 0.55
Of note, however, the strategy of antimycobacterial therapy intensification, as well as the contribution made by adjunctive agents in the management of MAC IRIS has not been verified in controlled, prospective trials.
IRIS Binding (management) of associated with immune reconstitution inflammatory syndrome
8) Confidence 0.24 Published 2007 Journal J Transl Med Section Body Doc Link PMC2213635 Disease Relevance 0.77 Pain Relevance 0.04
Furthermore, there has been a decline in incidence of MAC IRIS associated with the recent availability of potent HIV agents effective in those with late stage or highly resistant HIV infection.
IRIS Binding (associated) of associated with immune reconstitution inflammatory syndrome, acquired immune deficiency syndrome or hiv infection and infection
9) Confidence 0.23 Published 2007 Journal J Transl Med Section Body Doc Link PMC2213635 Disease Relevance 0.92 Pain Relevance 0
Even though IRIS is also closely associated with certain other infectious (mycobacteria, varicella zoster, herpesviruses, and cytomegalovirus) and non-infectious (autoimmune) conditions [2-10], the morbidity associated with HIV/tuberculosis (TB) is more important [1,11] as the crisis seem to be alarming in third-world nations, where the proportion of HIV/TB IRIS is reportedly high, ranging from 11% to 43% [12-15].
IRIS Binding (associated) of associated with mycobacterial infection, immune reconstitution inflammatory syndrome, acquired immune deficiency syndrome or hiv infection, herpes zoster and cytomegalovirus infection
10) Confidence 0.20 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 1.64 Pain Relevance 0.09
This has now been confirmed and extended by the growing body of recent microarray data, allowing to define a subgroup of sporadic breast cancers which exhibit bad prognosis and association with BRCA1 mutation or dysfunction (Gusterson et al. 2005; Diaz et al. 2007).
BRCA1 Binding (association) of in body associated with breast cancer
11) Confidence 0.18 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.70 Pain Relevance 0
Some studies suggest that circulating IL-6 levels prior to HAART may be associated with IRIS [53].
IRIS Binding (associated) of associated with immune reconstitution inflammatory syndrome
12) Confidence 0.18 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 1.16 Pain Relevance 0.30
The BRIP1 gene is involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.
BRCA1 Binding (association) of
13) Confidence 0.14 Published 2010 Journal J Neurooncol Section Body Doc Link PMC2945461 Disease Relevance 0.79 Pain Relevance 0
Association between IRIS and Death
IRIS Binding (Association) of associated with immune reconstitution inflammatory syndrome and death
14) Confidence 0.08 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 3.31 Pain Relevance 0.23
A challenge in pathogenesis studies such as ours is that the inflammatory profiles associated with IRIS are heterogeneous, representing a continuum that is likely dependent on the duration of symptoms, the antigen, and the robustness of the event.
IRIS Binding (associated) of associated with immune reconstitution inflammatory syndrome and inflammation
15) Confidence 0.08 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 1.48 Pain Relevance 0.38
Similar to a recent ACTG (AIDS Clinical Trial Group) a5164 trial, in our study timing of ART initiation was not associated with IRIS [54].
IRIS Binding (associated) of associated with immune reconstitution inflammatory syndrome and acquired immune deficiency syndrome or hiv infection
16) Confidence 0.06 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 2.45 Pain Relevance 0.12
IL-17) were a pre-ART risk for both IRIS and mortality on ART.
IRIS Binding (risk) of associated with immune reconstitution inflammatory syndrome
17) Confidence 0.06 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 1.24 Pain Relevance 0.03
Indeed, persons with IRIS had higher median serum CRAG titers when initiating ART than controls without IRIS (p?
IRIS Binding (persons) of associated with immune reconstitution inflammatory syndrome
18) Confidence 0.06 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 1.93 Pain Relevance 0.09
Among persons experiencing CM-IRIS, mortality after an IRIS event was associated with increased IL-10 levels (OR?
IRIS Binding (associated) of associated with cryptococcal meningitis and immune reconstitution inflammatory syndrome
19) Confidence 0.06 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 1.25 Pain Relevance 0
The anti-inflammatory mediator IL-1RA increased following ART initiation and before IRIS.
IRIS Binding (initiation) of associated with immune reconstitution inflammatory syndrome and inflammation
20) Confidence 0.06 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 1.68 Pain Relevance 0.34

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