INT22129

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 4.23
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CAT) small molecule metabolic process (CAT) aging (CAT)
Golgi apparatus (CAT) endoplasmic reticulum (CAT) peroxisome (CAT)
Anatomy Link Frequency
optic 4
brain 2
T cells 2
CAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 2 99.90 Very High Very High Very High
endometriosis 6 99.58 Very High Very High Very High
Morphine 6 99.56 Very High Very High Very High
agonist 1 99.52 Very High Very High Very High
Dopamine 10 98.92 Very High Very High Very High
Neurotransmitter 1 98.40 Very High Very High Very High
Neuritis 6 97.56 Very High Very High Very High
antagonist 3 93.12 High High
melanocortin 1 receptor 4 92.48 High High
Kinase C 1 75.76 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 11 100.00 Very High Very High Very High
Dysmenorrhea 2 99.90 Very High Very High Very High
Endometriosis (extended) 6 99.58 Very High Very High Very High
Rheumatoid Arthritis 1 98.68 Very High Very High Very High
Optic Neuritis 6 97.80 Very High Very High Very High
Endometrial Cancer 20 94.72 High High
Disease 13 89.76 High High
Neuroblastoma 2 89.68 High High
Myoma 21 89.64 High High
Polyps 24 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro, we found that expression of a transiently transfected human ppEnk promoter-driven chloramphenicol acetyltransferase (CAT) reporter construct was induced by DAergic agonists, as much as 20-fold.
Positive_regulation (induced) of Gene_expression (expression) of CAT associated with agonist
1) Confidence 0.67 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867759 Disease Relevance 0 Pain Relevance 0.51
OBJECTIVE: To determine if adenoviral-mediated transfer of the gene for catalase (CAT), the reactive oxygen species scavenger, suppresses experimental optic neuritis.
Positive_regulation (transfer) of Gene_expression (transfer) of CAT in optic associated with optic neuritis and neuritis
2) Confidence 0.67 Published 1999 Journal Arch. Ophthalmol. Section Abstract Doc Link 10565523 Disease Relevance 0.17 Pain Relevance 0.17
OBJECTIVE: To determine if adenoviral-mediated transfer of the gene for catalase (CAT), the reactive oxygen species scavenger, suppresses experimental optic neuritis.
Positive_regulation (transfer) of Gene_expression (transfer) of catalase in optic associated with optic neuritis and neuritis
3) Confidence 0.49 Published 1999 Journal Arch. Ophthalmol. Section Abstract Doc Link 10565523 Disease Relevance 0.17 Pain Relevance 0.17
The presence of H. pylori is confirmed by the presence of a gram negative curved bacilli and a positive test for urease, oxidase and catalase production.
Positive_regulation (test) of Gene_expression (production) of catalase
4) Confidence 0.49 Published 2004 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC543444 Disease Relevance 0.23 Pain Relevance 0
In our case, we cannot exclude the fact that transversion of CAT to AAT in position 179 of exon 5 may explain prolonged survival of a patient with good response to therapy.


Positive_regulation (transversion) of Gene_expression (transversion) of CAT
5) Confidence 0.49 Published 2003 Journal Oncology Section Body Doc Link 12837982 Disease Relevance 0 Pain Relevance 0
Morphine does not appreciably activate HIV/LTR-CAT expression in human MOLT-3 and other T cells.
Neg (not) Positive_regulation (activate) of Gene_expression (expression) of CAT in T cells associated with acquired immune deficiency syndrome or hiv infection and morphine
6) Confidence 0.49 Published 1990 Journal AIDS Res. Hum. Retroviruses Section Abstract Doc Link 2252636 Disease Relevance 1.54 Pain Relevance 0.53
CV-1 cells were stably transfected with a preproenkephalin A (PPE) promoter-chloramphenicol acetyltransferase (CAT) reporter plasmid containing -176 to +171 bp of the human PPE gene.
Positive_regulation (transfected) of Gene_expression (transfected) of CAT
7) Confidence 0.49 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8915585 Disease Relevance 0 Pain Relevance 0.11
Study of Ota et al. [12] showed that women with endometriosis and adenomyosis had elevated expression of CAT in comparison to healthy women but the expression did not show the usual, fluctuating pattern characteristic for the menstrual cycle.
Positive_regulation (elevated) of Gene_expression (expression) of CAT associated with endometriosis and dismenorea
8) Confidence 0.49 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805669 Disease Relevance 1.53 Pain Relevance 0.19
The increased cellular levels of catalase suppressed demyelination and blood-brain barrier disruption at the foci in the optic nerve where prior magnetic resonance imaging and histopathologic studies have demonstrated the demyelinating inflammation of experimental and human optic neuritis.
Positive_regulation (increased) of Gene_expression (levels) of catalase in brain
9) Confidence 0.45 Published 1999 Journal Arch. Ophthalmol. Section Body Doc Link 10565523 Disease Relevance 0 Pain Relevance 0
Pretreatment with alpha-MSH also increased the protein levels of catalase and ferritin.
Positive_regulation (increased) of Gene_expression (levels) of catalase
10) Confidence 0.29 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19659742 Disease Relevance 0.24 Pain Relevance 0.32
The catalase inhibitor 3-amino-1,2,4-triazole (3AT) abrogated DHC-induced expression of LC3-II, overexpression of the catalase gene increased expression of LC3-II protein, and knockdown decreased it.
Positive_regulation (overexpression) of Gene_expression (overexpression) of catalase
11) Confidence 0.13 Published 2008 Journal Autophagy Section Abstract Doc Link 18818525 Disease Relevance 0.34 Pain Relevance 0.38

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