INT2213

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Context Info
Confidence 0.54
First Reported 1979
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.72
Pain Relevance 4.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (EP300) transferase activity, transferring acyl groups (EP300) DNA binding (EP300)
cytoplasm (EP300) nucleolus (EP300) nucleus (EP300)
Anatomy Link Frequency
cholinergic neurons 1
temporal lobe 1
EP300 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 177 100.00 Very High Very High Very High
addiction 19 100.00 Very High Very High Very High
Opioid 66 99.04 Very High Very High Very High
methadone 159 98.08 Very High Very High Very High
adenocard 150 96.68 Very High Very High Very High
Paracetamol 9 93.72 High High
Analgesic 4 92.52 High High
alcohol 11 92.24 High High
Potency 2 92.12 High High
cerebral cortex 6 90.04 High High
Disease Link Frequency Relevance Heat
Drug Dependence 5 100.00 Very High Very High Very High
Sleep Disorders 316 99.78 Very High Very High Very High
Metabolic Encephalopathy 1 97.88 Very High Very High Very High
Respiratory Failure 30 97.84 Very High Very High Very High
Conduct Disorder 5 97.36 Very High Very High Very High
Alcohol Addiction 10 96.44 Very High Very High Very High
Cognitive Disorder 118 96.24 Very High Very High Very High
Nicotine Addiction 75 95.20 Very High Very High Very High
Aggression 2 90.52 High High
Mycobacterial Infection 2 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concomitant non-opioid drug use versus no concomitant drug use had no effect on P300 amplitudes (main effect group: p = 0.69, group × electrode interaction p = 0.88).
Neg (no) Regulation (effect) of P300 associated with opioid
1) Confidence 0.54 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 0.05 Pain Relevance 0.46
With regard to the first aim of our study we found no attenuation of P300 amplitudes or latencies between patients under methadone substitution treatment and control subjects.
Neg (no) Regulation (attenuation) of P300 associated with methadone
2) Confidence 0.39 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 0.46 Pain Relevance 0.98
The effects of T 200, T 150 + P 300, and T 100 + P 400 respectively could not be differentiated, indicating that the dose of tolmetin can be reduced markedly by simultaneous administration of paracetamol without a loss in analgesic potency.
Regulation (effects) of 150 + P 300 associated with paracetamol, analgesic and potency
3) Confidence 0.28 Published 1979 Journal Int J Clin Pharmacol Biopharm Section Abstract Doc Link 381221 Disease Relevance 0.35 Pain Relevance 1.50
Analyses revealed no significant effects of familial substance dependence on P300.
Neg (no) Regulation (effects) of P300 associated with drug dependence and addiction
4) Confidence 0.26 Published 1999 Journal Neuropsychopharmacology Section Abstract Doc Link 10379519 Disease Relevance 0.91 Pain Relevance 0.38
While the effect of sustained nicotine use on the P300 is not new, our study demonstrates, that nicotine use has to be controlled for in studies on cognitive function in patient samples.
Regulation (effect) of P300 associated with cognitive disorder and nicotine
5) Confidence 0.24 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 1.11 Pain Relevance 0.66
The finding in the intracranial recording studies that the peak of the focal activity recorded from the medial temporal lobe occurred 35–100 ms later than the positive peak recorded from the scalp [28,29,74] is noteworthy, indicating that the activity in this area is mainly responsible for the late part of the P300.


Regulation (responsible) of P300 in temporal lobe
6) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2607283 Disease Relevance 0.12 Pain Relevance 0.22
The effects of SD on N1 and P300 could thus be an effect of reduced cortical ACh levels caused by inhibition of the cholinergic neurons by AD.
Regulation (effect) of P300 in cholinergic neurons associated with adenocard and sleep disorders
7) Confidence 0.12 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.22 Pain Relevance 0.15
As was the case for N1, caffeine affects P300 in a manner opposite to that of SD.
Regulation (affects) of P300 associated with sleep disorders
8) Confidence 0.12 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.33 Pain Relevance 0.04
Of special importance is the fact that significant P300 latency changes were observed in association with various degrees of RF, including the mild or subclinical states.
Regulation (changes) of P300 associated with respiratory failure
9) Confidence 0.09 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2846153 Disease Relevance 0.93 Pain Relevance 0.08
This conclusion is further supported by the observation that both N1 and P300 are influenced by noradrenergic, dopaminergic, and cholinergic systems, i.e., systems which are known to mediate attention and arousal [81, 82].


Regulation (influenced) of P300
10) Confidence 0.05 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.24 Pain Relevance 0.03

General Comments

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