INT22132

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Context Info
Confidence 0.67
First Reported 1980
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 41
Total Number 41
Disease Relevance 18.64
Pain Relevance 10.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CAT) small molecule metabolic process (CAT) aging (CAT)
Golgi apparatus (CAT) endoplasmic reticulum (CAT) peroxisome (CAT)
Anatomy Link Frequency
SH-SY5Y 2
Erythrocytes 2
liver 2
optic nerve 2
blood 2
CAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 12 99.98 Very High Very High Very High
cva 8 99.60 Very High Very High Very High
fluoxetine 25 99.58 Very High Very High Very High
Nerve growth factor 3 99.28 Very High Very High Very High
agonist 25 99.20 Very High Very High Very High
dexamethasone 6 99.20 Very High Very High Very High
Chronic pancreatitis 4 98.20 Very High Very High Very High
ischemia 24 98.02 Very High Very High Very High
imagery 2 97.60 Very High Very High Very High
Angina 12 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 27 100.00 Very High Very High Very High
Metastasis 5 99.92 Very High Very High Very High
Disease 136 99.84 Very High Very High Very High
Stress 193 99.78 Very High Very High Very High
Targeted Disruption 7 99.64 Very High Very High Very High
Hemorrhage 3 99.60 Very High Very High Very High
Abscess 2 99.36 Very High Very High Very High
Injury 62 99.32 Very High Very High Very High
Lifespan 35 99.00 Very High Very High Very High
Cirrhosis 8 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased cellular levels of catalase suppressed demyelination and blood-brain barrier disruption at the foci in the optic nerve where prior magnetic resonance imaging and histopathologic studies have demonstrated the demyelinating inflammation of experimental and human optic neuritis.
Positive_regulation (increased) of catalase in brain
1) Confidence 0.67 Published 1999 Journal Arch. Ophthalmol. Section Body Doc Link 10565523 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Adenoviral-mediated gene transfer increased catalase levels in all optic nerve cell types, and it persisted for 1 month after inoculation.
Positive_regulation (increased) of catalase in optic nerve
2) Confidence 0.67 Published 1999 Journal Arch. Ophthalmol. Section Body Doc Link 10565523 Disease Relevance 0 Pain Relevance 0
RESULTS: After 1 month, cell-specific catalase activity, evaluated by the quantitation of catalase immunogold, was increased about 2-fold each in endothelia, oligodendroglia, astrocytes, and axons of the CAT-inoculated right optic nerves compared with the control left optic nerves.
Positive_regulation (increased) of catalase in optic nerves
3) Confidence 0.67 Published 1999 Journal Arch. Ophthalmol. Section Body Doc Link 10565523 Disease Relevance 0 Pain Relevance 0
During the carvedilol therapy, an increase in the SOD-1, GSH-Px and CAT activities was observed.
Positive_regulation (increase) of CAT
4) Confidence 0.67 Published 2008 Journal Cell. Mol. Biol. Lett. Section Abstract Doc Link 18026857 Disease Relevance 0.39 Pain Relevance 0.45
Erythrocyte CAT activity was increased by Na-salicylate, acemetacin, and tenoxicam at the therapeutic, and by dipyrone at the high concentration.
Positive_regulation (increased) of CAT in Erythrocyte
5) Confidence 0.67 Published 2001 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 11484831 Disease Relevance 0.25 Pain Relevance 0.80
CAT activity was only increased in the sera of patients with liver cirrhosis or pancreatitis, but not in the patients with concomitant cirrhosis and pancreatitis.
Neg (not) Positive_regulation (increased) of CAT in liver associated with cirrhosis and pancreatitis
6) Confidence 0.67 Published 2001 Journal Arch. Immunol. Ther. Exp. (Warsz.) Section Abstract Doc Link 11348018 Disease Relevance 1.58 Pain Relevance 0.35
Effects of the high dosage of marine drug on the changes were also observed, but the results were diverse, as the medicine changed significantly activities of CAT and GSH-Px (P<0.01) as well as content of MDA (P<0.05), and did not alter the activity of SOD (P>0.05).
Positive_regulation (changed) of CAT
7) Confidence 0.67 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2666885 Disease Relevance 0.06 Pain Relevance 0
Although not statistically significant, CAT activity was slightly increased as compared to baseline in both groups S and R.
Positive_regulation (increased) of CAT
8) Confidence 0.67 Published 2010 Journal Vojnosanit Pregl Section Body Doc Link 20845670 Disease Relevance 0 Pain Relevance 0
Morphine activation of HIV/LTR-CAT in the SH-SY5Y cells is not reversible by naltrexone and appears to involve a Fos/Jun signaling system.
Positive_regulation (activation) of CAT in SH-SY5Y associated with acquired immune deficiency syndrome or hiv infection and morphine
9) Confidence 0.67 Published 1990 Journal AIDS Res. Hum. Retroviruses Section Abstract Doc Link 2252636 Disease Relevance 1.57 Pain Relevance 0.58
Significant destabilization of the lysosomal membrane from baseline levels was evident at 5 and 10nM at the end of the exposures, as was a high induction capacity of the activities of CAT and GST.
Positive_regulation (induction) of CAT
10) Confidence 0.67 Published 2010 Journal Chemosphere Section Abstract Doc Link 20227746 Disease Relevance 0.16 Pain Relevance 0.07
The accumulation of choline acetyltransferase (CAT) proximal to and nerve growth factor (NGF) distal to the intraneural site of tetrodotoxin (TTX) or batrachotoxin (BTX) injection in vivo was used to monitor orthograde and retrograde axonal transport.
Positive_regulation (accumulation) of CAT in proximal associated with tetrodotoxin and nerve growth factor
11) Confidence 0.67 Published 1980 Journal Neurosci. Lett. Section Abstract Doc Link 6189020 Disease Relevance 0 Pain Relevance 0.48
During carvedilol therapy an increase in SOD-1, GSH-Px and CAT activities was observed.
Positive_regulation (increase) of CAT
12) Confidence 0.67 Published 2005 Journal Pol. Merkur. Lekarski Section Abstract Doc Link 17877121 Disease Relevance 0.31 Pain Relevance 0.39
The biochemical test results showed the organism to be catalase positive, tube coagulase negative, ornithine decarboxylase positive, slide coagulase positive, and latex agglutination tests for coagulase positive.
Positive_regulation (tests) of catalase in tube
13) Confidence 0.50 Published 2008 Journal The Korean journal of laboratory medicine Section Abstract Doc Link 18594171 Disease Relevance 0.92 Pain Relevance 0.09
If an acute hemorrhage is anticipated, an unenhanced CAT scan may be sufficient.
Positive_regulation (unenhanced) of CAT associated with cva
14) Confidence 0.49 Published 2008 Journal S D Med Section Abstract Doc Link 18819319 Disease Relevance 0.80 Pain Relevance 0.61
Over 60% of the patients had used CAT, and 25% used CAT on a regular basis.
Positive_regulation (used) of CAT
15) Confidence 0.49 Published 2008 Journal Eur. J. Neurol. Section Body Doc Link 19049557 Disease Relevance 0 Pain Relevance 0
Over 60% of the patients had used CAT, and 25% used CAT on a regular basis.
Positive_regulation (used) of CAT
16) Confidence 0.49 Published 2008 Journal Eur. J. Neurol. Section Body Doc Link 19049557 Disease Relevance 0 Pain Relevance 0
In brief, treatment with fluoxetine protects neuronal damage after transient ischemia, and the neuroprotective effect of fluoxetine in an ischemic animal model may be related with the up-regulation of BDNF, CAT, GPX, and SOD1 expression.
Positive_regulation (up-regulation) of CAT in neuronal associated with ischemia and fluoxetine
17) Confidence 0.49 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17328894 Disease Relevance 0.54 Pain Relevance 0.98
The treatment of 40 mg/kg fluoxetine in ischemic animals enhanced significantly BDNF, catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase-1 (SOD1) immunoreactivity in the CA1 region compared to those in the saline-treated group 4 days after ischemia/reperfusion.
Positive_regulation (enhanced) of CAT associated with ischemia and fluoxetine
18) Confidence 0.49 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17328894 Disease Relevance 0.63 Pain Relevance 1.30
Forskolin-induced CAT activity was attenuated by imipramine and fluoxetine and to a lesser degree by amitriptyline and desipramine in differentiated cells, whereas other drugs were inactive.
Positive_regulation (Forskolin-induced) of CAT associated with desipramine, endep and fluoxetine
19) Confidence 0.49 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14735130 Disease Relevance 0.06 Pain Relevance 0.56
Furthermore, mutations affecting almost all of these newly described enzymes appear to be as important for survival in the host as the well-studied traditional oxidative stress combating enzymes like CAT and superoxide dismutase (SOD).31
Positive_regulation (enzymes) of CAT associated with stress
20) Confidence 0.49 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768243 Disease Relevance 1.45 Pain Relevance 0

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