INT221351

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.88
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle 2
quadriceps 1
lung 1
neural 1
RT1-CE1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 7 99.10 Very High Very High Very High
Osteoarthritis 280 98.86 Very High Very High Very High
Inflammatory response 13 95.64 Very High Very High Very High
Central nervous system 8 93.20 High High
Inflammation 11 86.04 High High
Pain 51 78.72 Quite High
tolerance 2 76.24 Quite High
agonist 50 75.00 Quite High
Inflammatory mediators 1 74.12 Quite High
Nerve growth factor 58 71.24 Quite High
Disease Link Frequency Relevance Heat
Brain Hemorrhage 4 99.10 Very High Very High Very High
Osteoarthritis 275 98.86 Very High Very High Very High
INFLAMMATION 25 95.64 Very High Very High Very High
Hypertrophy 60 95.52 Very High Very High Very High
Disease 17 79.64 Quite High
Pain 41 78.72 Quite High
Weight Gain 20 75.12 Quite High
Injury 8 74.88 Quite High
Fibrosis 15 69.04 Quite High
Stroke 9 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine muscle fibre composition of the quadriceps, we monitored MHC protein expression.
Gene_expression (expression) of MHC protein in muscle
1) Confidence 0.19 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2849930 Disease Relevance 0.42 Pain Relevance 0.22
Clenbuterol administration exhibited an apparent 16% increase in total MHC protein expression relative to total protein (data not presented), although there was no change in the composition of the different MHC isoforms (Table I).


Gene_expression (expression) of MHC protein
2) Confidence 0.19 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2849930 Disease Relevance 0.27 Pain Relevance 0.07
MHC isoform protein expression was used as an index of muscle function.
Gene_expression (expression) of MHC isoform protein in muscle
3) Confidence 0.19 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2849930 Disease Relevance 0.13 Pain Relevance 0.03
Of interest we found that although no changes to the MHC protein composition were noted in response to clenbuterol prior to surgery, subtle effects of clenbuterol on MHC protein expression were observed in the period post surgery where clenbuterol suppressed the trend towards an MNX surgery-induced increase in MHC I.
Gene_expression (expression) of MHC protein
4) Confidence 0.19 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2849930 Disease Relevance 0.37 Pain Relevance 0.19
The present study shows that an NSC allograft might boost neural regeneration during focal cerebral ischemia in a rat model via the immuno-modulation of class I MHC expression by NSC-mediated neurotrophins and eventually lead to functional recovery without activating the caspase III inflammatory response.
Gene_expression (expression) of class I MHC in neural associated with brain hemorrhage, inflammatory response and ischemia
5) Confidence 0.15 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936305 Disease Relevance 0.47 Pain Relevance 0.35
Meniscal surgery resulted in the development of OA-like lesions, changes to weight bearing, and changes in MHC protein expression in the quadriceps.
Gene_expression (expression) of MHC protein in quadriceps associated with osteoarthritis
6) Confidence 0.15 Published 2010 Journal Osteoarthritis and Cartilage Section Abstract Doc Link PMC2849930 Disease Relevance 0.89 Pain Relevance 0.28
TNF-alpha increases class I MHC expression and has been associated with acute and chronic rejection in recipients of lung and other allografts [21,36-38].
Gene_expression (expression) of class I MHC in lung
7) Confidence 0.12 Published 2007 Journal Respir Res Section Body Doc Link PMC2213655 Disease Relevance 0.34 Pain Relevance 0.14

General Comments

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